摘要
目的观察慢性心力衰竭(CHF)病人血清可溶性基质裂解素2(sST2)的水平变化,探讨其与心功能的关系。方法入选2016年1月至2017年6月合肥市第一人民医院CHF住院病人76例,采用心脏彩色多普勒超声测量左室射血分数(LVEF)、左室舒张末内径(LVEDD),采用酶联免疫吸附法检测血清sST2水平;根据纽约心脏病学会(NYHA)心功能分级、LVEF、LVEDD进行分组,各组之间进行sST2水平比较。结果 CHF病人血清sST2水平在心功能Ⅱ[(0.47±0.32)ng/mL]、Ⅲ[(0.85±0.43) ng/mL]、Ⅳ[(1.41±0.57) ng/mL]级间差异有统计学意义,且随着心功能分级的升高而逐渐增高(均P<0.05);射血分数下降组血清sST2水平显著高于射血分数中间值组和射血分数保留组(均P<0.05),射血分数中间值组显著高于射血分数保留组(P<0.05);随着病人LVEDD增大,sST2水平显著升高(均P<0.05);sST2水平与LVEF呈负相关(r=-0.461,P<0.05),sST2与LVEDD呈正相关(r=0.436,P<0.05)。结论 sST2水平与CHF心功能状态有关,sST2水平可作为评估CHF严重程度的重要指标。
Objective To observe the levels of serum soluble ST2(sST2)in patient with chronic heart failure(CHF),and to investigate the correlation between sST2 and cardiac function.Methods Seventy-six patients with CHF hospitalized in the Department of Emergency,The First People s Hospital of Hefei from January 2016 and June 2017 were selected.Left ventricular ejection fraction(LVEF)and left ventricular end-diastolic diameter(LVEDD)were measured by cardiac color Doppler ultrasonography.Serum sST2 levels were determined by enzyme-linked immunosorbent assays.Results Serum sST2 levels among different heart functionⅡ[(0.47±0.32)ng/mL],Ⅲ[(0.85±0.43)ng/mL],Ⅳ[(1.41±0.57)ng/mL]showed significantly different,and increased gradually along with the rise of heart function in patient with CHF(P<0.05 for all).Patients with reduced ejection fraction(HFrEF)had significantly higher levels of sST2 than mid-range ejection fraction(HFmrEF)and preserved ejection fraction(HFpEF)(P<0.05 for all),HFmrEF higher the HFpEF(P<0.05).Additionally,the higher of serum sST2 levels,the increase of LVEDD in patient with CHF(P<0.05 for all).The serum sST2 levels were negatively correlated with LVEF(r=-0.461,P<0.05),but positively correlated with LVEDD(r=0.436,P<0.05).Conclusion Serum sST2 levels are closely related to cardiac function in patient with CHF,so it may be an important parameter reflecting the severity of CHF.
作者
李从圣
王勇
朱毅
张尧
聂开政
宋瑞
杨静
LI Congsheng;WANG Yong;ZHU Yi;ZHANG Yao;NIE Kaizheng;SONG Rui;YANG Jing(Department of Emergency,The Third Affiliated Hospital of Anhui Medical University/The First People s Hospital of Hefei,Hefei,Anhui 230061,China)
出处
《安徽医药》
CAS
2019年第4期654-656,共3页
Anhui Medical and Pharmaceutical Journal
基金
安徽省合肥市2016年度科技攻关计划资助项目(合科[2017]3号)
