摘要
目的:分析研究补中益气汤加味对肠结核患者的临床疗效。方法:选取肠结核患者80例按照随机双盲的原则均分为对照组和研究组。两组患者入院后均进行基础治疗,对照组40例采用常规四联抗结核药物治疗,研究组40例加用补中益气汤治疗,对两组患者治疗效果、不良反应发生率及治疗前后肠道炎症因子、肠黏膜屏障功能及T细胞亚群指标进行比较。结果:研究组的临床总有效率和不良反应发生率分别为92.50%(37/40)、15.00%(6/40),对照组分别为72.50%(29/40)、40.00%(16/40),差异均具有统计学意义(P<0.05)。治疗前,CD_3^+、CD_4^+、CD_8^+无明显差异(P>0.05),治疗后,研究组患者CD_3^+、CD_4^+水平均明显高于对照组,而CD_8^+水平明显低于对照组(P<0.05);治疗后,研究组患者血清C反应蛋白(CRP)水平和血清肿瘤坏死因子-α(TNF-α)及白介素-10(IL-10)水平均明显低于对照组,血D-乳酸和血二胺氧化酶(DAO)水平也明显低于对照组,差异具有统计学意义(P<0.05)。结论:肠结核患者在常规治疗的基础上加用补中益气汤加味治疗有助于改善患者的肠道屏障功能和T细胞亚群的免疫功能,缓解对机体肠道的损伤,疗效确切。
Objective:To analyze the clinical effect of Buzhong Yiqi decoction on patients with intestinal tuberculosis. Methods:Eighty patients with intestinal tuberculosis were selected and divided into control group and study group according to the principle of random double-blind. The two groups of patients underwent basic treatment after admission. 40 patients in the control group were treated with conventional four-drug therapy,and 40 patients in the study group were treated with Buzhong Yiqi decoction. The treatment effect and adverse reactions occurred in the two groups. The rates were compared with those of intestinal inflammatory factors,intestinal mucosal barrier function and T cell subsets before and after treatment. Results:The total clinical effective rate and adverse reaction rate of the study group were 92.50%(37/40) and 15.00%(6/40),respectively. The control group was 72.50%(29/40) and 40.00%(16/40),respectively. The differences were statistically significant ( P <0.05). After treatment,the levels of CD 3^+ and CD 4^+ in the study group were significantly higher than those in the control group,while the level of CD 8^+ was significantly lower than that in the control group ( P <0.05). The levels of CRP and TNF-α and IL-10 in the study group were significantly lower than those in the control group,and blood D-lactic acid and blood diamine were oxidized. The level of enzyme (DAO) was also significantly lower than that of the control group,and the difference was significant ( P <0.05). Conclusion:The addition of Buzhong Yiqi decoction on the basis of conventional treatment of intestinal tuberculosis patients is more helpful to improve the intestinal barrier function and immune function of T cell subsets,and to alleviate the damage to the intestinal tract of the body.
作者
景凤英
国福云
JING Fengying;GUO Fuyun(Shaanxi Tuberculosis Control Hospital(Shaanxi Fifth People’s Hospital),Xi’an 710100)
出处
《陕西中医》
2019年第4期496-498,共3页
Shaanxi Journal of Traditional Chinese Medicine
基金
陕西省卫生科研基金资助项目(2016D06410)
关键词
补中益气汤
肠结核
细胞亚群
血清C反应蛋白
肠道炎症因子
安全性
Buzhong Yiqi decoction
Intestinal tuberculosis
T cell subsets
Serum C-reactive protein
Intestinal inflammatory factors
Safety
