摘要
聚集过程对轴手性分子的手性光学信号有着重要的影响。1,1-联二萘分子随着聚集体的形成,其圆二色(CD)信号会被湮灭,简称聚集湮灭圆二色效应(AACD)。基于此,唐本忠教授和秦安军教授课题组设计了锁环和未锁环的4种基于联二萘的聚合物。从其聚集过程中CD谱图的变化可知,对于未锁环的分子(P-1,P-2),2个萘环之间的夹角会逐渐增大。相反,对于锁环的分子(P-3,P-4),相应的夹角会逐渐减小。分子动力学模拟结果也证实了聚集过程中这一构象变化。他们的工作为原位研究分子在聚集过程中构象的变化提供了一种高效、实时和定量的监测策略,这一手段将会在生命和健康领域有着巨大的应用前景。
The aggregation of molecules plays an important role in determining their functions.Electron microscopy and other methods can only characterize the variation of microstructure,but are not capable of monitoring conformational changes.These techniques are also complicated,expensive and time-consuming.Here,Prof.Tang and Prof.Qin’s group demonstrate a simple method to monitor in-situ and in real-time conformational change of(R)-1,1’-binaphthyl-based polymers during the aggregation process using circular dichroism.Based on the results from molecular dynamics simulations and experimental circular dichroism measurements,polymers with“open”binaphthyl rings show stronger aggregation-annihilated circular dichroism effects,with more negative torsion angles between the two naphthalene rings.In contrast,the polymers with“locked”rings show a more restrained aggregation-annihilated circular dichroism effect,with only a slight change of torsion angle.Prof.Tang and Prof.Qin’s work provides an approach to monitor molecular aggregation in a simple,accurate,and efficient way,which is expected to be applied in the areas of life and health.
作者
宛新华
WAN Xinhua(Beijing National Laboratory for Molecular Sciences,Key Laboratory of Polymer Chemistry and Physics of Ministry of Education,College of Chemistry and Molecular Engineering,Peking University,Beijing 100871,China)
出处
《功能高分子学报》
CAS
CSCD
北大核心
2019年第2期117-119,共3页
Journal of Functional Polymers
关键词
分子聚集
圆二色
构象变化
molecular aggregation
circular dichroism
conformational change
