摘要
趋化因子是一类在炎症与免疫反应中诱导白细胞募集的细胞因子家族。体外及动物实验证实,趋化因子参与视网膜病理损害过程。趋化因子与视网膜静脉阻塞(RVO)具有一定相关性,如白细胞介素8(IL-8)、单核细胞趋化蛋白1(MCP-1)、巨噬细胞炎性蛋白1(MIP-1)在RVO患眼中存在高表达现象,MCP-1、IL-8加重RVO继发黄斑水肿和视网膜缺血。针对RVO的治疗,曲安奈德(TA)及抗血管内皮生长因子(anti-VEGF)药物眼内应用亦被证实可抑制眼内部分趋化因子表达,且治疗效果与初始趋化因子水平具有一定相关性。本文将从上述几方面对趋化因子与RVO的相关性研究进展进行介绍。
Chemokines are a family of cytokines that induce leukocyte recruitment in inflammation and immune responses.Studies have confirmed that chemokines are associated with retinal vein occlusion(RVO),such as high expression of interleukin-8(IL-8),monocyte chemotactic protein-1(MCP-1)and macrophage inflammatory protein-1(MIP-1)in the eyes of RVO.Some chemokines,such as MCP-1 and IL-8 can aggravate macular edema and retinal ischemia in patients with RVO.For the treatment of RVO,the application of triamcinolone acetonide(TA)and anti-vascular endothelial growth factor(anti-VEGF)drugs has also been proved to inhibit the expression of some chemokines in the eyes,and the therapeutic effect is correlated with the level of initial chemokines.This article will introduce the research progress on the correlation between chemokines and RVO from the above aspects.
作者
刘明月(综述)
刘红玲(审校)
Liu Mingyue;Liu Hongling(Eye Hospital,the First Affiliated Hospital of Harbin Medical University,Harbin 150001,China)
出处
《中华实验眼科杂志》
CAS
CSCD
北大核心
2019年第3期238-240,共3页
Chinese Journal Of Experimental Ophthalmology
基金
白求恩·朗沐中青年眼科科研基金项目(BJ-LM2017002L).
