摘要
目的:探讨厄贝沙坦联合胺碘酮治疗心力衰竭合并心律失常的临床疗效。方法:选取2015年4月至2017年3月河南省唐河县人民医院收治的心力衰竭合并心律失常患者100例,根据盲抽法分为观察组和对照组,每组50例。对照组患者给予胺碘酮治疗,观察组患者在对照组的基础上加用厄贝沙坦治疗。6个月后,比较两组患者的临床疗效、心电图QT离散度、心功能指标水平[左心室舒张末期内径(LVEDD)、每搏输出量(SV)及左心室射血分数(LVEF)]和不良反应发生情况的差异。结果:观察组患者的总有效率为96.00%(48/50),明显高于对照组的80.00%(40/50),差异有统计学意义(P<0.05);治疗后,观察组患者的心电图QT离散度、LVEDD明显低于对照组,SV、LVEF明显高于对照组,差异均有统计学意义(P<0.05);观察组、对照组患者不良反应发生率分别为6.00%(3/50)、10.00%(5/50),差异无统计学意义(P>0.05)。结论:厄贝沙坦联合胺碘酮治疗心力衰竭合并心律失常,可提高临床疗效,改善患者心功能指标水平,且不良反应少,安全性较高。
OBJECTIVE:To probe into the clinical efficacy of irbesartan combined with amiodarone in treatment of heart failure complicated with arrhythmia.METHODS:100 patients with heart failure complicated with arrhythmia admitted into Henan Tanghe County People's Hospital from Apr.2015 to Mar.2017 were selected and divided into observation group and control group via blind extraction method,with 50 cases in each.The control group was treated with amiodarone,while the observation group was given irbesartan combined with amiodarone.After 6-month treatment,the differences in clinical efficacy,QT dispersion of electrocardiogram,cardiac function indices[left ventricular end-diastolic dimension(LVEDD),stroke volume(SV)and left ventricular ejection fraction(LVEF)]and incidences of adverse drug reactions between two groups were compared.RESULTS:The total effective rate of observation group was 96.00%(48/50),which was significantly higher than that of the control group(80.00%,40/50),with statistically significant difference(P<0.05);after treatment,the QT dispersion of electrocardiogram and LVEDD of observation group were significantly lower than those of the control group,while the SV and LVEF of observation group were significantly higher,with statistically significant differences(P<0.05);the incidences of adverse drug reactions of observation group and control group were respectively 6.00%(3/50)and 10.00%(5/50),the difference had no statistical significance(P >0.05).CONCLUSIONS:The combination of irbesartan and amiodarone can improve the clinical efficacy in treatment of heart failure complicated with arrhythmia,which can promote patients'cardiac function,with few adverse drug reactions and high safety.
作者
李果
LI Guo(Dept.of Cardiovascular Medicine,Henan Tanghe County People's Hospital,Henan Tanghe 473400,China)
出处
《中国医院用药评价与分析》
2019年第1期50-52,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
