摘要
目的利用生物信息学技术探讨p53在宫颈癌的突变、共表达网络及在疾病预后中的预测能力,为宫颈癌的诊断与预后判断提供一定的理论基础。方法利用癌症基因组图谱数据库对靶标分子p53进行检索,发现其突变及可能的作用分子与网络。结果 p53基因在宫颈癌中的突变率约为9%,通过STRING在线数据库找到在宫颈癌中与p53互作分子Bcl2,p53的表达水平与宫颈癌预后呈正相关。结论本研究发现了与p53共同发挥生物学功能的相关分子Bcl2,为宫颈癌的早期诊断、靶向治疗及预后判断提供了一定理论基础。
Objective To explore the role of p53 for its mutation,co-expression network and its prognostic ability in cervical cancer,and to provide a theoretical basis for the diagnosis and prognosis of cervical cancer.Methods The target molecule p53 was searched using The Cancer Genome Atlas(TCGA)database to identify its mutations,possible molecules and networks.Results The mutation rate of p53 gene in cervical cancer was about 9%.The expression level of p53 interacting molecule Bcl2 and p53 in cervical cancer is positively correlated with the prognosis of cervical cancer in STRING database.Conclusion This study showes that Bcl2 may play an important biological role together with p53 in cervical cancer,by which to provide a theoretical basis for early diagnosis,targeted therapy and prognosis of cervical cancer.
作者
赵子骞
梁新苗
张飞跃
赵培庆
ZHAO Zi-qian;LIANG Xin-miao;ZHANG Fei-yue;ZHAO Pei-qing(Shandong Zibo Experimental High School,Shandong 255036,China;Department of Gynaecology,Zibo Central Hospital,Shandong 255036,China;Center of Translational Medicine,Zibo Central Hospital,Shandong 255036,China)
出处
《中国医药生物技术》
2019年第1期27-32,共6页
Chinese Medicinal Biotechnology
基金
山东省自然科学基金面上项目(ZR2015HM031
ZR2014HM042)
山东省医药卫生科技发展计划(2016WSA03022)
