摘要
产前诊断为在出生前预测胎儿是否患有某些遗传性疾病或先天畸形的方法,又称宫内诊断。诊断时间越早,操作创伤性越小,对孕妇及胎儿越有利。通过微创方法收集宫颈脱落滋养层细胞,对其进行形态学、免疫学、遗传学等分析,可确定其胎源性来源并实现孕早期胎儿遗传病的诊断,从而达到产前诊断早期、微创的目的。本文就近年来基于宫颈脱落滋养层细胞的微创性产前诊断进展做一综述。
Prenatal diagnosis is an approach of predicting whether the fetus has certain genetic diseases or congenital malformations before birth,also known as intrauterine diagnosis.The earlier the diagnosis is,the less traumatic the operation is,and the more beneficial to pregnant women and fetuses.By collecting cervical exfoliated trophoblast cells by minimally invasive method and analyzing their morphology,immunology and genetics,we can determine their fetal origin and realize the diagnosis of fetal genetic diseases in early pregnancy,so as to achieve the goal of early and minimally invasive prenatal diagnosis.In this paper,we review the progress of minimally invasive prenatal diagnosis based on cervical exfoliative trophoblast cells in recent years.
作者
李丹
兰风华
LI Dan;LAN Fenghua(Department of Clinical Genetics and Experimental Medicine,PLA Institute of Clinical Laboratory Medicine,Dongfang Hospital Affiliated to Xiamen University,Fuzhou,Fujian 350025,China)
出处
《国际检验医学杂志》
CAS
2019年第5期597-600,共4页
International Journal of Laboratory Medicine
基金
福建省科技引导性项目(2016Y0071)
关键词
产前诊断
滋养层细胞
遗传分析
先天畸形
宫颈
prenatal diagnosis
trophoblast cells
genetic analysis
congenital malformations
cervical
