摘要
目的探讨晚期肺腺癌胸苷酸合成酶(TS)和亚甲基四氢叶酸还原酶(MTHFR)基因多态性的表达及与培美曲塞联合铂类治疗的疗效分析。方法入组晚期肺腺癌患者58例,25例检测TS和MTHFR基因的多态性并分析其与化疗疗效及无进展生存期的关系。结果 58例患者的疾病控制率(DCR)38%,中位无进展生存期(PFS)8.1个月。TS基因多态性2R/2R型16%、2R/3R型32%、3R/3R型52%;3R/3R型、2R/2R+2R/3R型DCR分别为53.8%和91.7%(P=0.046);PFS分别为9.3和10.4个月(P>0.05)。MTHFR基因多态性C/T型52%,C/C型40%,TT型8%;MTHFR基因C/C型、C/T+T/T型DCR分别为70.0%和73.3%;PFS分别为10.0和9.7个月(P> 0.05)。结论 TS基因多态性与培美曲塞联合铂类治疗晚期肺腺癌DCR可能相关,而与PFS无相关性;MTHFR基因多态性与培美曲塞联合铂类治疗晚期肺腺癌DCR、PFS未发现相关性。
Objective To investigate the expressions of thymidylate synthase(TS)and methylene tetrahy-drofolate reductase(MTHFR)polymorphisms and the therapeutic efficacy of chemotherapy with pemetrexed and platinum in advanced lung adenocarcinoma patients. Methods Fifty-eight patients with advanced lung adenocarcinoma were enrolled in this study. The blood samples from 25 of them were examined for extraction of DNA. The associations of the gene polymorphisms with the chemotherapy efficacy and PFS were analyzed. Results Disease control rate was noted by 38% and the median time of progression-free survival was 8.1 months among 58 patients. There were 16%,32%,52%,and TS genotypes as 2R/2R,2R/3R and 3R/3R respectively;the difference in the control rate between those with TS gene of 3R/3R and those with TS gene of 2R/2R+2R/3R was significant statistically(53.8% vs. 91.7%,P = 0.046),but the difference in PFS was statistically insignificant(9.3 vs. 10.4 months, P > 0.05). There were 40%,52%,8%,and MTHFR genotypes as CC,CT and TT respectively. The DCR in those with MTHFR CC and C/T + T/T was 70% and 73.3%,respectively and PFS was 10 months and 9.7 months respectively,showing no significant difference(P > 0.05). Conclusion The TS gene polymorphism is associated with therapeutic effect of pemetrexed for advanced lung adenocarcinoma,but MTHFR is not.
作者
白丽艳
韩军
王冬梅
祁玉娟
BAI Liyan;HAN Jun;WANG Dongmei;QI Yujuan(Department of Oncology,Qinghai Provincial People′s Hospital,Xining 810007,China)
出处
《实用医学杂志》
CAS
北大核心
2019年第4期520-524,共5页
The Journal of Practical Medicine
基金
青海省人民医院院级课题项目(编号:20150916)
关键词
晚期肺腺癌
基因多态性
培美曲塞
亚甲基四氢叶酸还原酶
胸苷酸合成酶
advanced lung adenocarcinoma
genetic polymorphis
pemetrexed
methylene tetrahydrofolate reductase
thymidylate synthase
