摘要
目的:分析非小细胞肺癌脑转移瘤患者影响其治疗疗效和生存预后的因素。方法:分析2013年1月～2017年1月在我院肿瘤科收治的105例NSCLC脑转移患者,收集可能影响其疗效的不同治疗方法及预后的相关危险因素,并进行随访研究。结果:单因素分析结果提示KPS评分、肺原发肿瘤控制情况、原发病治疗方法、T分期、脑转移灶数目(单发或多发)、有无贫血、有无吸烟史、有无脑转移症状、确诊肺癌到脑转移间隔时间(年)、脑转移瘤治疗方案及脑转移灶的近期疗效对患者生存期有影响(P <0. 05),多因素分析显示KPS评分、有无贫血、有无吸烟史、脑转移瘤治疗方案、肺原发肿瘤控制情况、确诊肺癌到脑转移间隔时间(年)有关(P <0. 05)。结论:KPS评分、有无贫血、有无吸烟史、脑转移瘤治疗方案、肺原发肿瘤控制情况、确诊肺癌到脑转移间隔时间(年)是非小细胞肺癌脑转移患者独立的预后因素。研究表明非小细胞肺癌脑转移患者良好的生存预后因素包括KPS评分≤60分、无贫血、无吸烟史、联合治疗(放疗+化疗)、单发脑转移、脑转移灶的近期疗效较好、原发灶控制良好以及确诊肺癌到脑转移间隔时间(年)≤1年,这些患者平均生存年龄较长,生存质量较好。
Objective:To analyse The factors influencing the therapeutic efficacy and survival prognosis of patients with brain metastases from non-small cell lung cancer.Methods:105 patients with brain metastases from January 2013 to January 2017 in our oncology department were analyzed.Risk factors associated with treatment and prognosis were followed up.Results:univariate analysis showed that KPS score,control of primary lung tumor,T stage of primary treatment,number of brain metastases (single or multiple),anemia or not.No smoking history,no symptoms of brain metastasis,time between lung cancer and brain metastasis (years),treatment regimen of brain metastases,and short-term curative effect of brain metastases had influence on survival time of patients (P<0.05).Multivariate analysis showed KPS score,anemia or not.The history of smoking,the treatment of brain metastases,the control of primary lung tumors,and the interval between lung cancer and brain metastasis were related (P<0.05).Conclusion:KPS score,anemia,history of smoking,treatment of brain metastases,control of primary lung tumors,time between lung cancer and brain metastasis,and brain metastases from non-small cell lung cancer (NSCLC) were confirmed.It was an independent prognostic factor.Good prognostic factors in patients with brain metastasis from non-small cell lung cancer included KPS score≤60,no anemia,no smoking history,combined therapy (radiotherapy and chemotherapy),single brain metastasis,and better short-term curative effect.The average survival age and quality of life of the patients with well-controlled primary lesions and the interval between lung cancer and brain metastasis were less than 1 year.
作者
魏岚
高望朔
霍永生
WEI Lan;GAO Wang-shuo;HUO Yong-sheng(Yijishan Hospital of Wannan Medical College,Wuhu,Anhui 241000)
出处
《赣南医学院学报》
2019年第1期17-21,共5页
JOURNAL OF GANNAN MEDICAL UNIVERSITY
关键词
非小细胞肺癌
脑转移
预后
危险因素
nonsmall-cell lung cancer
brain metastases
prognosis
risk factor
