摘要
[目的]探讨孕早期血脂水平与子痫前期发生的相关性.[方法]选取2015年1月1日至2015年12月31日在上海交通大学医学院附属国际和平妇幼保健院建卡分娩的子痫前期孕妇272例作为研究组,同时选取同期分娩的健康妊娠孕妇300例作为对照组.检测2组孕妇孕(11+3)周～(13+6)周血清总胆固醇(total cholesterol, TC)、甘油三酯(triglyceride,TG)、高密度脂蛋白(high density lipoprotein, HDL)、低密度脂蛋白(low density lipoprotein,LDL)、载脂蛋白A(apolipoprotein A, ApoA)、载脂蛋白B(apolipoprotein B, ApoB)及脂蛋白a(lipoprotein a, LPa),计算动脉粥样硬化指数(atherosclerosis index, AI), TC/HDL,TG/HDL, LDL/HDL及ApoB/ApoA并进行比较.利用受试者工作特征(receiver oper-ating characteristic, ROC)曲线进行检测指标预测子痫前期评价.[结果]子痫前期组TG, LDL, ApoB, AI, TC/HDL, TG/HDL, LDL/HDL及ApoB/ApoA均明显高于正常妊娠组(P <0.05). 2组TC, LPa, HDL及ApoA无统计学差异(P> 0.05). ROC曲线确定TG/HDL对子痫前期有预测价值(P <0.05),曲线下面积(area under the curve,AUC)为0.843,最佳临界值为1.49,灵敏度为67.7%,特异度为91.7%.[结论]子痫前期患者孕早期存在高血脂异常代谢, TG/HDL对子痫前期发生有预测价值.
[Objective]To explore the connection between blood lipid levels in early pregnancy and the risk of preeclampsia.[Methods]To analyze 272 cases with preeclampsia who received routine examination and gave birth in International Peace Maternity and Child Health Hospital,Shanghai Jiao Tong University School of Medicine from January to December in 2015.Controls were 300 healthy pregnant women at the same stage of delivery.The levels of serum total cholesterol(TC),triglyceride(TG),high density lipoprotein(HDL),low density lipoprotein(LDL),apolipoprotein A(ApoA),apolipoprotein B(ApoB)and lipoprotein a(LPa)were detected in early pregnancy((11+3)^(13+6)weeks),and atherosclerosis index(AI),TC/HDL,TG/HDL,LDL/HDL and ApoB/ApoA were calculated.The receiver operating characteristic(ROC)curve was used to predict preeclampsia.[Results]The levels of TG,LDL,ApoB,AI,TC/HDL,TG/HDL,LDL/HDL and ApoB/ApoA of the preeclampsia group were significantly higher than those of the control group(P<0.05).There were no significant differences in the levels of TC,LPa,HDL and ApoA between the two groups(P >0.05).The ROC curve indicated that TG/HDL had predictive value for preeclampsia(P<0.05).Area under the curve(AUC)was 0.843,the critical value was 1.49,sensitivity 67.7%,specificity 91.7%.[Conclusion]Patients with preeclampsia had significant abnormal hyperlipidemia metabolism in early pregnancy.TG/HDL may be a reference predictor of the risk of preeclampsia.
作者
林楠
顾玮
华人意
侯燕燕
LIN Nan;GU Wei;HUA Renyi;HOU Yanyan(Department of Gynaecology and Obstetrics,International Peace Maternity and Child Health Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200030,China)
出处
《上海大学学报（自然科学版）》
CAS
CSCD
北大核心
2019年第1期18-23,共6页
Journal of Shanghai University:Natural Science Edition
基金
国家自然科学青年基金资助项目(81300513)
上海市科委中西医引导类课题项目(15411964200)
关键词
血脂
子痫前期
孕早期
blood lipid
preeclampsia
early pregnancy
