摘要
免疫治疗在晚期肝细胞癌中表现出了更好的治疗效果以及更小的毒副作用,因而免疫单药或联合治疗成为该领域备受期待的治疗方法。本文就晚期肝细胞癌免疫治疗的现状及未来发展方向进行综述,着重介绍免疫检查点抑制剂、溶瘤病毒、溶瘤细菌、肿瘤免疫疫苗、免疫细胞治疗及联合治疗等在肝细胞癌治疗中的研究及应用进展,以期为肝细胞癌患者制定个性化治疗方案提供借鉴。
Immunotherapy possesses better therapeutic efficacy and induces less toxic side effects in treatment of advanced hepatocellular carcinoma(HCC), therefore immunological monotherapy or combination therapy has become a highly anticipated treatment in this field. This article reviews the current status and future of immunotherapy for advanced HCC, introduces the researches and application progress of immune checkpoint blockage, oncolytic viruses, oncolytic bacteria, tumor immunization vaccine, immune cell therapy and combination therapy in treatment of HCC, with the expectation of providing reference for HCC patients’ individualized therapy.
作者
刘淦
孙杰
张婷
卢姗姗
向姣
曾珍
陆荫英
白文林
LIU Gan;SUN Jie;ZHANG Ting;LU Shan-shan;XIANG Jiao;ZENG Zhen;LU Yin-ying;BAI Wen-lin(Comprehensive Liver Cancer Center,the Fifth Medical Center of Chinese PLA General Hospital,Beijing 100039,China;Department of Pathology,960 Military Hospital of China,Jinan 250000,China)
出处
《传染病信息》
2019年第1期87-95,共9页
Infectious Disease Information
基金
"精准医学研究"重点专项计划(2017YFC0908400)
"十三五"国家科技重大专项(2018ZX10302205
2018ZX10723204)
关键词
肝细胞肝癌
免疫治疗
溶瘤病毒
联合治疗
hepatocellular carcinoma
immunotherapy
oncolytic viruses
combination therapy
