摘要
目的了解IgE介导过敏婴幼儿在每天补充400 IU维生素D情况下25(OH)D水平及其影响因素,为制定过敏儿童维生素D合理补充方案提供依据。方法对598例每天补充400 IU维生素D的0～24个月IgE介导过敏儿进行血清25(OH)D水平检测,并选取158例健康婴幼儿做对照,填写自制调查表,采用c2检验、t检验、方差分析和SNK检验、多因素线性回归分析补充400 IU维生素D时,IgE介导过敏儿的25(OH)D水平与健康儿童有无差别,并且分析IgE介导过敏儿的25(OH)D水平与性别、年龄、季节、遗传因素以及过敏的不同症状表现等因素之间的关系。结果补充400 IU维生素D时IgE介导过敏婴幼儿25(OH)D水平与健康儿均在正常范围,两者差异无统计学意义;IgE介导过敏婴幼儿25(OH)D水平:四季中春季低于夏季;男孩低于女孩;婴儿期低于13月龄以上的;多因素线性回归示女孩、年龄增加及存在营养不良者25(OH)D数值增加。结论每日补充400 IU维生素D可维持IgE介导过敏婴幼儿25(OH)D水平在正常范围,北方地区春季、发育正常、婴儿期的过敏儿在维生素D疾病防治过程中要给予格外关注。
Objective To investigate 25 (OH) D level in IgE-mediated allergy children and analyze its influencing factors on the premise of daily supplementation of 400 IU vitamin D,and to provide a basis for formulating reasonable supplemental regimen for vitamin D in children with allergy. Methods Serum 25 (OH) D levels were measured in 598 children with IgE-mediated allergy in 0-24 months old and 158 healthy children as the control group. Fill in the self-made questionnaire, Chi square test, t test, ANOVA, SNK test and multivariate linear regression analysis were used to analyze. The 25 (OH) D levels in IgE-mediated allergy children were compared with healthy children when supplemented with 400 IU vitamin D,.and explore the factors influencing of 25 (OH) D levels in IgE-mediated allergy children including sex, age, genetic factors, seasons and different symptoms of allergy. Results The 25 (OH) D levels in IgE-mediated allergy children and healthy infants were within the normal range when supplemented with 400 IU vitamin D, and there were no significant difference between them. The 25 (OH) D levels in IgE-mediated allergy children comparision:boys are lower than girls;spring is lower than summer in four seasons;below 12 month old is lower than 13 month old;multivariate linear regression showed that 25 (OH) D increased in girls, age and malnutrition. Conclusion Daily supplementation of 400 IU vitamin D can maintain 25 (OH) D levels of IgE-mediated allergy children in normal range. The allergic children in spring, normal development and infancy in northern China should pay special attention to the prevention and treatment of vitamin D disease.
作者
田晓博
Tian Xiaobo(Shenyang Maternal and Child Hospital, Shenyang, Liaoning, 110011, China)
出处
《当代医学》
2019年第7期28-31,共4页
Contemporary Medicine
