摘要
目的研究克罗恩病(CD)初诊患者贫血的临床特点。方法选择我院2015年8月至2018年2月收治的122例初次确诊的CD患者为研究对象,分析住院CD患者的贫血情况,并探究贫血程度与CD蒙特利尔分型及大便隐血试验结果的关系;总结克罗恩病疾病活动指数(CDAI)及CD简化内镜评分(SES-CD)与HGB、MCHC、MCH、MCV、RDW、ESR的关系。结果 122例初次确诊CD患者中,有75.41%(92/122)的患者存在不同程度的贫血,以轻度贫血为主,无重度和极重度贫血;男女患者贫血比例为1.63∶1。不同贫血程度CD患者的大便隐血发生率无显著差异(P=0.261)。在CDAI中,轻度、中度活动期CD患者的MCH、MCV、ESR与缓解期比较,差异均具有统计学意义(P<0.05)。在SES-CD中,轻度、中度、重度活动期CD患者的HGB、MCH、MCHC、RDW与缓解期比较,差异均具有统计学意义(P<0.05)。结论 CD患者以轻度贫血为主;CD患者贫血与肠道黏膜出血关系不大。通过对CD患者的MCH、MCV、ESR水平检测可对患者的疾病严重程度作出评估,通过HGB、MCHC、MCH、RDW检测可对CD患者肠道黏膜作出评估。
Objective To study the clinical characteristics of anemia in newly diagnosed patients with Crohn's disease(CD).Methods A total of 122 patients with CD who were initial diagnosis in our hospital from August 2015 to February 2018 were selected as study objects,the anemia status of CD patients in our hospital were analyzed,and the relationships between anemia degree and CD Montreal typing and stool occult blood test results were explored;the relationships between Crohn's disease activity index(CDAI)and CD simplified endoscopy score(SES-CD)and HGB,MCHC,MCH,MCV,RDW,ESR were summarized.Results Among 122 patients with newly diagnosed CD,75.41%(92/122)had different degrees of anemia,mainly mild anemia,without severe and extremely severe anemia,and the anemia rate of male and female patients was 1.63∶1.There was no significant difference in the incidence of occult fecal blood among CD patients with different degrees of anemia(P=0.261).In CDAI,the levels of MCH,MCV and ESR in mild and moderate active stage CD patients were significantly different from those in remission stage(P<0.05).In SES-CD,there were significant differences in the levels of HGB,MCH,MCHC and RDW between mild,moderate and severe active stage CD patients and remission stage(P<0.05).Conclusion The patients with CD mainly have mild anemia.There is little relationship between anemia and intestinal mucosal bleeding in CD patients.The severity of disease can be assessed by detecting the levels of MCH,MCV and ESR in CD patients.The intestinal mucosa of CD patients can be assessed by detecting HGB,MCHC,MCH and RDW.
作者
王陆军
吴正祥
WANG Lu-jun;WU Zheng-xiang(Gastroenterology Department,Provincial Hospital Affiliated to Anhui Medical University,Hefei 230031,China)
出处
《临床医学研究与实践》
2019年第5期17-19,22,共4页
Clinical Research and Practice
