期刊文献+

独活寄生汤口服联合玻璃酸钠关节腔注射治疗早中期膝骨关节炎 被引量:15

Oral application of Duhuo Jisheng Tang (独活寄生汤) combined with intra-articular injection of sodium hyaluronate for treatment of early-middle knee osteoarthritis
下载PDF
导出
摘要 目的:观察独活寄生汤口服联合玻璃酸钠关节腔注射治疗早中期膝骨关节炎(knee osteoarthritis,KOA)的临床疗效及对氧化应激指标的影响。方法:将106例符合要求的早中期KOA患者随机分为2组。联合组(54例)采用独活寄生汤口服联合玻璃酸钠关节腔注射治疗,玻璃酸钠组(52例)采用玻璃酸钠关节腔注射治疗。独活寄生汤水煎服,每日1剂,连续治疗5周;玻璃酸钠关节腔注射治疗每周1次,连续治疗5周。评定患者的骨关节炎严重性指数(index of severity for osteoarthritis,ISOA)、膝关节疼痛视觉模拟量表(visual analogue scale,VAS)评分及总体疗效,测定血清超氧化物歧化酶(superoxide dismutase,SOD)、丙二醛、谷胱甘肽(glutathione,GSH)水平及总抗氧化能力(total antioxidant capacity,T-AOC)。结果:①临床疗效。治疗前2组患者的ISOA比较,差异无统计学意义(t=0. 397,P=0. 692);治疗结束后2组患者的ISOA均较治疗前降低[(6. 38±1. 48)分,(1. 42±0. 39)分,t=23. 814,P=0. 000;(6. 49±1. 37)分,(2. 11±0. 56)分,t=21. 340,P=0. 000],联合组的ISOA低于玻璃酸钠组(t=7. 384,P=0. 000)。治疗前2组患者的膝关节疼痛VAS评分比较,差异无统计学意义(t=0. 303,P=0. 763);治疗结束后2组患者的膝关节疼痛VAS评分均较治疗前降低[(6. 10±1. 21)分,(2. 05±0. 64)分,t=21. 742,P=0. 000;(6. 03±1. 17)分,(2. 95±0. 83)分,t=15. 483,P=0. 000],联合组的膝关节疼痛VAS评分低于玻璃酸钠组(t=6. 226,P=0. 000)。联合组的总体疗效优于玻璃酸钠组(R珔联合组=47. 37,R珔玻璃酸钠组=59. 87,Z=-2. 205,P=0. 027)。②氧化应激指标。治疗前2组患者的血清SOD水平比较,差异无统计学意义(t=0. 284,P=0. 777);治疗结束后2组患者的血清SOD水平均较治疗前升高[(65. 37±9. 33)单位·mL^(-1),(97. 58±12. 46)单位·mL^(-1),t=15. 103,P=0. 000;(64. 83±10. 21)单位·mL^(-1),(78. 45±9. 47)单位·mL^(-1),t=7. 099,P=0. 000],联合组的血清SOD水平高于玻璃酸钠组(t=8. 874,P=0. Objective:To observe the clinical curative effects of oral application of Duhuo Jisheng Tang(独活寄生汤,DHJST)combined with intra-articular injection of sodium hyaluronate in the treatment of early-middle knee osteoarthritis(KOA)and its effects on oxidative stress indexes.Methods:One hundred and six patients with early-middle KOA were enrolled in the study and were randomly divided into combination therapy group(54 cases)and sodium hyaluronate group(52 cases),and were treated with combination therapy of oral application of DHJST and intra-articular injection of sodium hyaluronate and monotherapy of intra-articular injection of sodium hyaluronate respectively.The DHJST decoctions were taken one dose a day for consecutive 5 weeks.The intra-articular injections of sodium hyaluronate were performed on patients once a week for consecutive 5 weeks.The index of severity for osteoarthritis(ISOA),knee pain visual analogue scale(VAS)scores and the total curative effects were evaluated.The serum levels of superoxide dismutase(SOD),malondialdehyde(MDA)and glutathione(GSH)and the total antioxidant capacity(T-AOC)were measured.Results:There was no statistical difference in ISOA between the 2 groups before the treatment(t=0.397,P=0.692).The ISOA decreased in the 2 groups after the end of the treatment compared to pretreatment(6.38+/-1.48 vs 1.42+/-0.39 points,t=23.814,P=0.000;6.49+/-1.37 vs 2.11+/-0.56 points,t=21.340,P=0.000),and the ISOA were lower in combination therapy group compared to sodium hyaluronate group(t=7.384,P=0.000).There was no statistical difference in knee pain VAS scores between the 2 groups before the treatment(t=0.303,P=0.763).The knee pain VAS scores decreased in the 2 groups after the end of the treatment compared to pretreatment(6.10+/-1.21 vs 2.05+/-0.64 points,t=21.742,P=0.000;6.03+/-1.17 vs 2.95+/-0.83 points,t=15.483,P=0.000),and the knee pain VAS scores were lower in combination therapy group compared to sodium hyaluronate group(t=6.226,P=0.000).The combination therapy group surpassed the sodi
作者 周江涛 赵依娜 王庆来 ZHOU Jiangtao;ZHAO Yina;WANG Qinglai(Wenzhou Hospital of Traditional Chinese Medicine,Wenzhou 325000,Zhejiang,China)
机构地区 温州市中医院
出处 《中医正骨》 2019年第2期17-21,共5页 The Journal of Traditional Chinese Orthopedics and Traumatology
基金 2015年浙江省中医药科技计划项目(2015ZQ031)
关键词 骨关节炎 独活寄生汤 透明质酸 氧化应激 临床试验 osteoarthritis,knee Duhuo Jisheng Tang hyaluronic acid oxidative stress clinical trial
  • 相关文献

参考文献14

二级参考文献167

共引文献804

同被引文献183

引证文献15

二级引证文献102

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部