摘要
帕金森病(PD)是最常见的慢性不可逆的多器官神经退行性疾病,与整个神经系统和许多器官中的α突触核蛋白的异常形成相关。临床上以运动和非运动特征为特征,自主神经系统功能障碍是PD最常见的非运动症状之一,可出现在PD早期或前驱阶段,通常发生在PD临床诊断前的10年或更长时间。因此,自主神经系统功能障碍的症状有助于PD的早期诊断、评估疾病严重程度、预后和预测对治疗的反应。目前国内外对于PD患者自主神经功能障碍的研究较少。
Parkinson’s disease(PD),a common chronic and irreversible multi-organ neurodegenerative disorder associated withα-synuclein deposits throughout the nervous system and many organs,is clinically characterized by motor and nonmotor features.Autonomic dysfunction symptoms are the common non-motor symptoms of PD,which may appear in early/prodromal stage of the disease,often preceding the clinical diagnosis of PD by a decade or more.Therefore,autonomic dysfunction symptoms are helpful for the early diagnosis,assessment of disorder severity,prognosis,and prediction of response to therapy.So far,the research on PD autonomic symptoms is rare both in China and abroad.
作者
米热古丽.依力哈木
玛依努尔.买买提
MIREGULI Yilihamu;MAYINUER Maimaiti(Xinjiang Medical University,Urumqi 830000,China;Department of Neurology,Xinjiang Uygur Autonomous Region People′s Hospital,Urumqi 830000,China)
出处
《医学综述》
2019年第3期545-549,555,共6页
Medical Recapitulate
关键词
帕金森病
非运动症状
自主神经功能障碍
Parkinson′s disease
Non-motor symptom
Autonomic nerve dysfunction
