摘要
目的:评价阿利沙坦酯片治疗轻中度原发性高血压患者颈动脉粥样硬化(CAS)病变的疗效。方法:入选在我院就诊的轻中度原发性高血压伴CAS患者120例。以随机法分为:缬沙坦组(60例,口服缬沙坦80mg/d)和阿利沙坦酯组(60例,口服阿利沙坦酯片240mg/d),总疗程48周。治疗前,治疗24周、48周时行颈部血管超声检查,并对结果进行比较。结果:与治疗前比较,两组治疗24周、48周后的IMT值、颈动脉斑块大小、颈动脉斑块厚度和颈动脉斑块个数均显著减小,且48周上述指标值显著小于24周的(P<0.05或<0.01);阿利沙坦酯组IMT的下降值显著大于缬沙坦组,但两组的颈动脉斑块大小、厚度及个数无显著差异(P均>0.05)。结论:两种药物对颈动脉斑块大小、厚度及个数的疗效相当;但阿利沙坦酯片对IMT的疗效显著优于缬沙坦。
Objective:To evaluate therapeutic effect of allisartan isoproxil tablet on carotid atherosclerosis(CAS)lesion in patients with mild to moderate essential hypertension(EH).Methods:A total of 120 patients with mild to moderate EH complicated CAS treated in our hospital were enrolled.They were randomly divided into valsartan group(n=60,received valsartan 80mg/d)and allisartan isoproxil group(n=60,received allisartan isoproxil tablet 240mg/d),both groups received measure by carotid vascular ultrasound before treatment,24 weeks and 48 weeks after treatment and its result were compared between two groups.Results:Compared with before treatment,there were significant reductions in IMT,size,thickness and number of carotid atherosclerotic plaques on 24 weeks and 48 weeks after treatment in two groups,and above indexes of 48 weeks were significantly lower than those of 24 weeks,P﹤0.05 or﹤0.01.The decreased value of IMT in allisartan isoproxil group was significantly higher than that of valsartan group,and there were no significant difference between two groups in time point of size,thickness and number of carotid atherosclerotic plaques,P﹥0.05 all.Conclusion:Therapeutic effect of two drugs on size,thickness and number of carotid atherosclerotic plaques are similar;but therapeutic effect of allisartan isoproxil tablet on IMT is significantly better than that of valsartan.
作者
席婷
姬学光
周静
屈文静
巩红
董香婷
马丽
刘婷
王巧丽
XI Ting;JI Xue-guang;ZHOU Jing;Qu Wen-jing;GONG Hong;DONG Xiang-ting;MA Li;LIU Ting;Wang Qiao-li(First Ward of Coronary Heart Disease,Cardio-cerebral Vascular Specific Ward,Affiliated Hospital of Yan'an University,Yan'an,Shaanxi,716000,China)
出处
《心血管康复医学杂志》
CAS
2019年第1期46-51,共6页
Chinese Journal of Cardiovascular Rehabilitation Medicine
关键词
高血压
颈动脉疾病
阿利沙坦酯
Hypertension
Carotid artery Dis
Allisartan isoproxil
