摘要
目的:对虾青素进行毒理学安全性评价,为其食用安全性提供科学依据。方法:通过急性经口毒性试验、Ames试验、骨髓细胞微核试验、精子畸形试验和大鼠30d喂养试验等毒理学评价试验,评估虾青素的食用安全性。结果:虾青素对雌、雄大鼠的急性经口最大耐受量(MTD)均大于19.0g/kg·BW。Ames试验、小鼠骨髓微核试验和精子畸形试验结果均未见该样品有致突变作用,大鼠30d喂养试验各项指标也均未见明显毒性反应。结论:虾青素急性毒性分级属无毒级,无遗传毒性,在该实验研究剂量和条件下,虾青素未见明显毒副作用。
Objective To assess the toxicological safety of astaxanthin.Method The toxicity was determined by transoral acute toxicity,Ames test,bone marrow cell micronucleus test in mice,and sperm abnormality test,and 30-day feeding experiment.Result The maximum tolerated dose(MTD)of astaxanthin on male and female rats were all larger than 19.0g/kg·BW.The results of Ames test,mouse bone marrow micronucleus test and detection of chromosome aberration experiment were negative.For the 30 days oral toxicity test,the parameters were in the range of normal value.Conclusion No significant toxic effects are found for astaxanthin in this study.
作者
石丽丽
韩超
赵金鹏
李岩
SHI Li-li;HAN Chao;ZHAO Jin-peng;LI Yan(National Institute for Nutrition and Health,Chinese Center for Disease Control and Prevention,Beijing 100051,China)
出处
《中国食物与营养》
2019年第1期31-35,共5页
Food and Nutrition in China
关键词
虾青素
毒性试验
安全评价
astaxanthin
toxicological experiment
security assessment
