摘要
目的探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)与夜间咽喉反流(LPR)的相关性。方法选择2016年1月～2017年12月在我院接受治疗的52例OSAHS患者作为研究对象,监测患者整夜睡眠呼吸情况、行24 h咽喉pH值以及高分辨食管动力检查,探讨OSAHS与LPR的相关性。结果 52例患者中有13例存在LPR,LPR患者OSAHS严重程度与患者咽喉pH平均值呈现出明显的负相关(P<0.05);LPR患者上食道括约肌(UES)静息压及下食管括约肌(LES)静息压分别为(71.13±9.25)mmHg、(27.39±11.14)mmHg,均显著低于非LPR患者,差异有统计学意义(P<0.05)。结论阻塞性睡眠呼吸暂停低通气综合征患者病情程度与夜间咽喉反流密切相关,其夜间容易诱发胃食管反流,伴随咽喉部pH值下降,需给予高度临床关注。
Objective To investigate the association between obstructive sleep apnea hypopnea syndrome(OSAHS)and nocturnal pharyngeal reflux(LPR).Methods A total of 52 patients with OSAHS who were treated in our hospital from January 2016 to December 2017 were enrolled in the study.The patients were monitored for sleep and breathing,24-hour throat pH,and high-resolution esophageal motility examination to explore the relevance of OSAHS and LPR.Results LPR was found in 13 of 52 patients.The severity of OSAHS in LPR patients was significantly negatively correlated with the mean pH of the patients(P<0.05).The resting pressure of upper esophageal sphincter(UES)resting pressure and lower esophageal sphincters in LPR patients was(71.13±9.25)mmHg and(27.39±11.14)mmHg,respectively,which was significantly lower than that of non-LPR patients.The difference was statistically significant(P<0.05).Conclusion The degree of disease in patients with obstructive sleep apnea hypopnea syndrome is closely related to nocturnal regurgitation.It is easy to induce gastroesophageal reflux at night,and the pH value of the throat decreases.It requires high clinical attention.
作者
傅中明
王华英
俞万钧
FU Zhongming;WANG Huaying;YU Wanjun(Department of Respiratory and Critical Care Medicine,Ningbo Yinzhou People's Hospital,Ningbo 315040,China)
出处
《中国现代医生》
2019年第2期5-7,11,共4页
China Modern Doctor
基金
浙江省医药卫生科技计划项目(2017KY617)
