摘要
目的:探究妊娠晚期B族链球菌(GBS)带菌者敏感抗生素预防性治疗时机的选择及对临床治疗结果的影响。方法:选取2016年7月-2017年7月本院收治的妊娠晚期GBS检测阳性者180例作为研究对象,其中未接受任何治疗者60例设置为A组,在孕35～37周时给予抗生素预防性治疗者60例设置为B组,在临产或胎膜早破时给予抗生素治疗者60例设置为C组。分别观察三组间两两比较的妊娠结局,包括胎膜早破、早产、宫内感染、新生儿感染、产褥感染及剖宫产情况。结果:B、C组的胎膜早破、早产、宫内感染、新生儿感染、产褥感染及剖宫产情况均明显优于A组,差异均有统计学意义(P<0.05)。B、C组胎膜早破、早产、宫内感染、新生儿感染情况比较,差异均无统计学意义(P>0.05);但C组产褥感染、剖宫产情况均明显低于B组,差异均有统计学意义(P<0.05)。结论:临床对妊娠晚期GBS带菌者在临产或胎膜早破时给予敏感抗生素预防性治疗能够显著提高妊娠结局。
Objective:To explore the selection of time for prophylactic treatment of sensitive antibiotics for group B streptococcal(GBS)carriers in the late pregnancy and its effect on the outcome of clinical treatment.Method:A total of 180 cases of GBS positive in the late pregnancy admitted in our hospital from July 2016 to July 2017 were selected as the research objects.60 cases of them did not received any treatment as group A,60 cases were given antibiotic prophylactic treatment at 35-37 weeks of pregnancy as group B and 60 cases were given antibiotic treatment at the time of parturient or premature rupture of membranes as group C.Premature rupture of membranes,premature delivery,intrauterine infection,neonatal infection,puerperal infection and cesarean section pregnancy outcomes of two-to-two comparisons among the three groups were observed.Result:The premature rupture of membranes,premature delivery,intrauterine infection,neonatal infection,puerperal infection and cesarean section in group B and C were significantly better than those in group A,the differences were statistically significant(P<0.05).There were no significant differences in premature rupture of membranes,premature delivery,intrauterine infection and neonatal infection between group B and C(P >0.05);but the puerperal infection and cesarean section in group C were significantly lower than those in group B,the differences were statistically significant(P<0.05).Conclusion:The prophylactic treatment with sensitive antibiotics for GBS carriers in the late pregnancy at the time of parturient or premature rupture of the membranes can significantly improve pregnancy outcomes.
作者
林秀美
LIN Xiumei(Shaoguan Maternal and Child Health Hospital Family Planning Service Center,Shaoguan 512026,China)
出处
《中国医学创新》
CAS
2019年第5期133-136,共4页
Medical Innovation of China
基金
广东省医学情报研究所立项课题(44011120172911K)
关键词
妊娠晚期
B族链球菌带菌者
敏感抗生素
预防性治疗
时机选择
结局
Late pregnancy
Group B Streptococcus carriers
Sensitive antibiotics
Prophylactic treatment
Selection of time
Outcome
