摘要
目的建立以柚皮苷为内标的一测多评方法,用以验证该方法在小儿消积止咳口服液质量评价中的准确性及可行性。方法以柚皮苷为内标,分别建立柚皮苷与橙皮苷、新橙皮苷的相对较正因子,计算小儿消积止咳口服液中橙皮苷、新橙皮苷的量,实现一测多评。同时采用外标法测定小儿消积止咳口服液中3种黄酮类成分的量,并比较计算值与实测值的差异,以验证一测多评法在测定中的科学性及可行性。结果各相对校正因子重复性良好,一测多评法测定结果与外标法测定结果无显著性差异。结论以柚皮苷为内标同时测定橙皮苷、新橙皮苷的一测多评法可用于小儿消积止咳口服液的定量分析。
OBJECTIVE To establish a method for simultaneously determination for the content of three flavones in Xiao'er Xiaoji Zhike Oral Liquid by single marker,which is feasible and accurate.METHODS Taking naringin as internal standard substance,to establish a method for quantitative analysis of multi-components(QAMS)with single marker to determinate the content of naringin,hesperidin,and neohespridin in Xiao'er Xiaoji Zhike Oral Liquid.The contents in three batches of samples were determined by both external standard method and QAMS.The scientificity and feasibility of the method were evaluated by comparison of the quantitative results between external standard method and QAMS.RESULTS The relative correction factor(RCF)was perfect.The results calculated with a single marker were consistent with the results by the external standard method.CONCLUSION The method with a single marker is accurate and feasible to evaluate the quality of Xiao'er Xiaoji Zhike Oral Liquid.
作者
陆林玲
钱叶飞
LU Lin-ling;QIAN Ye-fei(Suzhou Institute for Food and Drug Control,Suzhou 215104,China)
出处
《海峡药学》
2019年第1期62-64,共3页
Strait Pharmaceutical Journal
关键词
一测多评
小儿消积止咳口服液
柚皮苷
橙皮苷
新橙皮苷
相对校正因子
Quantitative analysis multi-components by single marker
Xiao'er Xiaoji Zhike Oral Liquid
Naringin
Hesperidin
Neohespridin
Relative correction factor
