摘要
目的:探讨联合检测儿童难治性支原体肺炎(RMPP)肺泡灌洗液(BALF)白细胞介素-8(IL-8)、白细胞介素-10(IL-10)及干扰素-γ(INF-γ)的意义。方法:回顾性分析2016年11月-2018年5月本院收治的RMPP患儿65例的临床资料为研究组,其中行支气管肺泡灌洗35例为A组,行支气管肺泡灌洗无效再接受激素治疗的30例患儿为B组。将同期行支气管肺泡灌洗的肺炎支原体肺炎患儿45例设为对照组。结果:研究组患儿BALF中细胞总数、上皮细胞及中性粒细胞比例均显著高于对照组(P<0.05),但淋巴细胞、嗜酸性粒细胞和巨噬细胞比例和对照组比较差异均无统计学意义(P>0.05);治疗前,研究组BALF中的IL-8、INF-γ水平均高于对照组,IL-10水平低于对照组(P<0.05);治疗后,B组患儿IL-8、INF-γ水平均高于A组,IL-10水平低于A组(P<0.05);研究组患儿BALF中的IL-8、INF-γ水平与疗效呈负相关,而IL-10水平与疗效呈正相关。结论:难治性支原体肺炎患儿BALF中的IL-8、IL-10及INF-γ会出现异常表达,各指标水平与患儿的疗效有密切关系,值得推广和应用。
Objective:To explore the significance of combined detection of interleukin-8(IL-8),interleukin-10(IL-10)and interferon-γ(IFN-γ) in bronchoalveolar lavage fluid(BALF)of refractory Mycoplasma pneumonia (RMPP) in children.Method:The clinical data of sixty-five children with refractory Mycoplasma pneumonia admitted to our hospital from November 2016 to May 2018 were retrospectively analyzed(the study group).Thirty-five children who underwent bronchoalveolar lavage were selected as group A,thirty children who underwent bronchoalveolar lavage but failed to respond to hormone therapy were selected as group B,and the bronchoalveolar lavage bronchoalveolar bronchoalveolar bronchoalveolar bronchoalveolar 45 children with protoplast pneumonia were selected as the control group.Result:The proportion of total cells,epithelial cells and neutrophils in BALF of the study group was significantly higher than those of the control group (P<0.05),but there were no significant differences in the proportion of lymphocytes,eosinophils and macrophages between the study group and the control group (P >0.05).Before treatment,the levels of IL-8 and INF-γin BALF of the study group were higher than those of the control group,and the levels of IL-10 was higher than that of the control group,there were significant differences in two groups (P<0.05).After treatment,the levels of IL-8 and INF-γin group B were higher than those in group A,and the levels of IL-10 were lower than those in group A,there were significant differences in two groups (P<0.05).The levels of IL-8 and INF-γin BALF in study group were negatively correlated with the curative effect,while the levels of IL-10 was positively correlated with the curative effect.Conclusion:The abnormal expression of IL-8,IL-10 and INF-γin BALF of children with refractory Mycoplasma pneumonia is closely related to the curative effect of children,which is worth of popularizing and applying.
作者
许柏华
胡婷
梁燕
刘清彪
XU Baihua;HU Ting;LIANG Yan(Dongguan Tung Wah Hospital,Sun Yat-sen University,Dongguan 523110,China)
出处
《中国医学创新》
CAS
2019年第4期129-132,共4页
Medical Innovation of China
基金
东莞市社会科技发展(一般)项目(201750715046005)
