摘要
目的探讨对Ⅲ期结肠癌患者实施完整结肠系膜切除的疗效及对术后复发及转移率的影响。方法将2013年1月至2018年1月筛选的120例Ⅲ期结肠癌患者根据随机数字表法分为常规组(n=60,传统结肠癌根治术手术)和干预组(n=60,完整结肠系膜切除)。分析比较两组患者的手术指标、术后康复进程、术后并发症发生情况、肿瘤标志物水平、生活质量、肿瘤复发及转移情况。结果干预组的手术出血量明显少于常规组,淋巴结清扫数量明显多于常规组(P<0.05)。两组患者手术时间、术后排气时间、术后排便时间、引流管拔除时间、术后住院时间及术后并发症总发生率比较,差异不显著(P>0.05)。术后1个月,两组患者血清CEA及CA19-9水平均显著降低,生活质量评分均升高,且干预组优于常规组(P<0.05)。干预组术后6个月的肿瘤复发率及转移率与常规组比较,差异不显著(P>0.05)。结论对Ⅲ期结肠癌患者实施完整结肠系膜切除的近远期疗效良好,且术后复发及转移率低,值得临床推广应用。
Objective To investigate the efficacy of complete mesorectal excision in the treatment of patients with stageⅢcolon cancer and its influence on the rates of postoperative recurrence and metastasis.Methods A total of 120 patients with stageⅢcolon cancer selected from January 2013 to January 2018 were divided into routine group(n=60,traditional radical resection of colon cancer)and intervention group(n=60,complete mesorectal excision)according to random number table method.The operation indexes,rehabilitation process,postoperative complications,levels of tumor markers,quality of life,tumors recurrence and metastasis were analyzed and compared between the two groups.Results The amount of operative bleeding in the intervention group was significantly less than that in the routine group,and the number of lymph node dissection was significantly more than that in the routine group(P<0.05).There were no significant differences in operation time,postoperative exhaust time,defecation time,drainage tube removal time,hospitalization time and total incidence of complications between the two groups(P >0.05).One month after operation,the levels of serum CEA and CA19-9 in both groups decreased significantly,and the quality of life score increased,and those of the intervention group were better than the routine group(P<0.05).There were no significant differences in the rates of tumor recurrence and metastasis between the intervention group and the routine group at 6 months after operation(P >0.05).Conclusion Complete mesorectal excision in the treatment of stageⅢcolon cancer has good short-term and long-term effects,with low rates of tumor recurrence and metastasis.It is worthy of clinical promotion and application.
作者
马全仓
张毅
MA Quan-cang;ZHANG Yi(Central Hospital of Chenghe Mining Bureau, Weinan 715200;No.215 Hospital of Shaanxi Nuclear Industry,Xianyang 712000, China)
出处
《临床医学研究与实践》
2019年第3期6-8,共3页
Clinical Research and Practice
关键词
Ⅲ期结肠癌
完整结肠系膜切除
传统结肠癌根治术
stageⅢcolon cancer
complete mesorectal excision
traditional radical resection of colon cancer
