摘要
背景:目前,对于后路椎间盘镜下病灶清除、抗生素人工骨植入联合一期经皮椎弓根螺钉内固定治疗化脓性椎间盘炎尚无报道。目的:评估后路椎间盘镜下病灶清除、抗生素人工骨植入联合一期经皮椎弓根螺钉内固定治疗化脓性椎间盘炎的临床疗效。方法:选择2014年1月至2017年12月广州医科大学附属第一医院脊柱外科收治的31例化脓性椎间盘炎患者,其中男17例,女14例,年龄28-78岁,均行后路椎间盘镜下病灶清除、抗生素人工骨植入、一期经皮椎弓根螺钉内固定治疗。术后随访检查血沉及C-反应蛋白水平,同时进行目测类比评分与日本骨科协会JOA腰椎功能评分。结果与结论:①31例患者均顺利完成手术,所有患者术后腰痛及下肢放射痛得到即刻缓解,术后1-4 d均可佩戴腰围下地活动;②31例患者术后获得9-18个月随访,所有患者术后1周的C-反应蛋白及血沉均较术前明显下降,术后1,3,6个月的C-反应蛋白及血沉均在正常范围内;③31例患者术后1周及末次随访时的目测类比评分均明显低于术前(P <0.05),JOA腰椎功能评分均明显高于术前(P <0.05);④随访复查CT及MRI检查,31例患者无复发及假关节形成,无内固定无松动;⑤结果说明,后路椎间盘镜下病灶清除、抗生素人工骨植入联合一期经皮椎弓根螺钉内固定治疗化脓性腰椎间盘炎,创伤小、出血少、疼痛缓解迅速,患者可早期下地活动,具有良好的临床效果。
BACKGROUND: There is no report on the treatment of suppurative discitis with posterior microendoscopic discectomy, antibiotic artificial bone implantation and one-stage percutaneous pedicle screw fixation. OBJECTIVE: To evaluate the clinical effectiveness of posterior microendoscopic debridement, antibiotic artificial bone implantation and one-stage percutaneous pedicle screw fixation for pyogenic spondylodiscitis. METHODS: Thirty-one patients with suppurative discitis admitted at the Department of Spinal Surgery, the First Affiliated Hospital of Guangzhou Medical University from January 2014 to December 2017, including 17 males and 14 females, aged 28-78 years, were included. All the patients underwent posterior microendoscopic lesion clearance and antibiotic artificial bone grafting and one-stage percutaneous pedicle screw fixation. The erythrocyte sedimentation rate and C-reactive protein levels were detected at postoperative follow-up. The Visual Analog Scale and the Japanese Orthopaedic Association scores were used for detection. RESULTS AND CONCLUSION:(1) All the surgical operations of the 31 patients were successfully completed and all patients had immediate relief of low back pain and lower extremity radiation pain. They were able to move ground wearing a waistband at 1-4 days postoperatively.(2) Thirty-one patients were followed up for 9-18 months. All patients had a significant decrease in C-reactive protein and erythrocyte sedimentation rate at 1 week after surgery, and C-reactive protein and erythrocyte sedimentation rate were in the normal range at 1, 3, and 6 months postoperatively.(3) The Visual Analog Scale scores of all patients at 1 week of follow-up were significantly lower than those before surgery (P < 0.05), and the Japanese Orthopaedic Association scores were significantly higher than those before surgery (P < 0.05).(4) In the follow-up examination of CT and MRI, there was no recurrence, pseudoarticular formation or internal fixation loosening.(5) These results suggest that posterior microe
作者
姚立权
凌钦杰
李家颖
钟乐天
周兴平
刘锦滔
何二兴
尹知训
Yao Liquan;Ling Qinjie;Li Jiaying;Zhong Letian;Zhou Xingping;Liu Jintao;He Erxing;Yin Zhixun(Department of Spinal Surgery, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, Guangdong Province, China)
出处
《中国组织工程研究》
CAS
北大核心
2019年第14期2133-2139,共7页
Chinese Journal of Tissue Engineering Research
基金
广东省科技厅科技计划项目(2014A020212369)
项目负责人:尹知训
广州市科信局应用基础项目(2013J4100041)
项目负责人:尹知训~~
