摘要
环状RNA(circRNA)是在真核细胞中广泛存在的普遍且多样的内源性非编码RNA。它们形成共价闭合、连续稳定的环状结构,能够发挥miRNA分子海绵作用,调控基因转录和选择性剪接。这些分子为治疗干预提供了新的潜在机会并且可以作为诊断的生物标记物。该文综述了circRNA的形成和功能及其检测方法,总结circRNA在神经系统疾病、心血管疾病、癌症及感染等发生和发展中的生物学作用,为在诊断中circRNA的潜在使用提供证据。
Circular RNAs (circRNAs) are universal and diverse endogenous non-coding RNAs which widely found in eukaryotic cells.They form covalently closed,continuous and stable ring structure,which play the role of microRNA (miRNA) molecular sponge and regulate gene transcription and selective splicing.These molecules offer new potential opportunities for therapeutic intervention and serve as biomarkers for diagnosis.This paper provides an overview of the formation,function and detection methods of circRNAs,and summarizes the biological role of circRNAs in the development and progression of diseases such as nervous system diseases,cardiovascular diseases,cancer and infection,and provides evidence for the potential use of circRNAs in diagnosis.
作者
孙畅
张朝霞
SUN Chang;ZHANG Zhaoxia(Medical Laboratory Center,First Affiliated Hospital of Xinjiang Medical University,Urumqi,Xinjiang 830054,China)
出处
《国际检验医学杂志》
CAS
2019年第2期234-239,共6页
International Journal of Laboratory Medicine
基金
国家自然科学基金资助项目(81460323)
新疆维吾尔自治区自然科学基金资助项目(2017D01C314)
