摘要
目的探讨Let-7家族各成员与乳腺癌患者预后相关性,寻找更有效的乳腺癌防治分子靶标。方法利用KaplanMeier plotter在线数据库分析Let-7家族各成员(Let-7a、7b、7c、7d、7e、7f、7g、7i、miR-98、miR-202)表达与乳腺癌患者总生存期(OS)及临床病理参数的相关性,并得出相应的危险比(HR)、95%置信区间(CI)和P值。结果 Let-7a、Let-7b、Let-7c、Let-7e、Let-7f、Let-7g、miR-98高表达或miR-202低表达的患者有较好的OS(P<0.05);病理特征分析显示,Let-7a、Let-7b、Let-7f、Let-7g、miR-98、miR-202的表达与疾病临床分期存在相关性(P<0.05)。Let-7a、Let-7b、Let-7c、Let-7e、Let-7f、Let-7g、miR-98和miR-202与淋巴结表达存在相关性(P<0.05);三阴乳腺癌患者OS则与Let-7b、Let-7c、Let-7g、miR-202表达显著相关(P<0.05)。结论 Let-7与乳腺癌患者OS显著相关,各成员在乳腺癌中的预后判断中具有不同的价值,其中Let-7b、Let-7g、miR-202在不同临床参数及三阴乳腺癌中都显示出与预后密切相关,更有望成为乳腺癌防治靶标。
Objective To explore the expression of miRLet-7 family members in breast cancer and its correlation with overall survivals(OS),and to find more effective molecular targets for breast cancer prevention and treatment.Methods Kaplan-Meier(KM)plotter online database was used to analyze the correlation among the expression of Let-7 family members(Let-7a,7b,7c,7d,7e,7f,7g,7i,miR-98,miR-202)correlated with overall survival(OS)and the prognosis and clinical pathological parameters of breast cancer patients,and Hazard ratio(HR),95%confidence interval(CI),and P value were determined.Results The study showed that the high expression level of Let-7a,Let-7b,Let-7c,Let-7e,Let-7f,Let-7g,miR-98 and the low expression level of miR-202 was associated with better OS for breast cancer patients(P<0.05).We further assessed the prognostic value of Let-7 in different subtypes and clinical stage.The expression of Let-7a,Let-7b,Let-7f,Let-7g,miR-98,miR-202 was related to clinical stage(P<0.05).Let-7a,Let-7b,Let-7c,Let-7e,Let-7f,Let-7g,miR-98 and miR-202 was related to lymph node status(P<0.05).In triple-negative breast cancers(TNBC),with breast cancer subtype,the expression of Let-7b,Let-7c,Let-7g and miR-202 was significantly correlated to overall survival(P<0.05).Conclusion The Let-7 is significantly correlated with OS in breast cancer patients.The results suggested that members of the Let-7 have different values in predicting the prognosis of breast cancer.Among them,Let-7b,Let-7g and miR-202 are closely related with clinical stage and TNBC,and might promote development of Let-7 as targeted inhibitors for the treatment of breast cancer.
作者
耿淼
潘静坤
罗芸
田磊
王建华
GENG miao;PAN Jing-kun;LUO Yun;TIAN Lei;WANG Jian-hua(Institute of Geriatrics,Second Medical Center of Chinese PLA General Hospital,Beijing 100853,China)
出处
《局解手术学杂志》
2019年第1期1-5,共5页
Journal of Regional Anatomy and Operative Surgery
基金
国家重点研发计划课题(2016YFC1303603)
