摘要
目的探讨血清内脏脂肪素(Visfatin)、核因子-κB(NF-κB)与不稳定型心绞痛(UA)患者血小板活化参数的关系。方法选取2017年4月～2018年9月邯郸市第二医院收治的UA患者108例作为心绞痛组,选取同期健康体检者108名作为健康组。两组纳入者均在入院当天采血检测血清Visfatin、NF-κB及血小板颗粒膜蛋白(CD63)、血小板膜糖蛋白Ⅱb～Ⅲa(PAC-1)、血小板α颗粒表面膜糖蛋白(CD62P)水平。比较低、中、高危患者血清Visfatin、NF-κB与血小板活化参数,采用Pearson线性相关分析观察UA患者血清Visfatin、NF-κB与血小板活化参数的相关性。结果心绞痛组血清Visfatin、NF-κB及CD63、PAC-1、CD62P水平高于健康组,差异有高度统计学意义(P <0.01)。低危组血清Visfatin、NF-κB及CD63、PAC-1、CD62P水平低于中危组、高危组,且中危组低于高危组,差异有统计学意义(P <0.05)。经Pearson线性相关分析发现血清Visfatin、NF-κB与CD63、PAC-1呈正相关(r=0.671、0.591、0.507、0.460,P <0.05),二者与CD62P未见明显相关性(P> 0.05)。结论 Visfatin、NF-κB与UA患者血小板活化参数CD63、PAC-1具有相关性,临床可将Visfatin、NF-κB与血小板活化参数作为评估UA患者病情的重要指标。
Objective To investigate the relationship between platelet activation parameters of serum Visfatin,nuclear factor-κB(NF-κB)and unstable angina pectoris(UA).Methods From April 2017 to September 2018,in the Second Hospital of Handan,108 UA patients were selected as angina group,at the same time,108 healthy patients underwent physical examination were selected as the health group.In the two groups,blood samples were collected on the day of admission to detect serum Visfatin,NF-κB and platelet granule membrane protein(CD63),platelet membrane glycoproteinⅡb-Ⅲa(PAC-1),platelet alpha particle surface membrane glycoprotein(CD62P).Serum Visfatin,NF-κB and platelet activation parameters of low,middle and high risk patients were compared.The correlation between serum Visfatin and NF-κB and platelet activation parameters in UA patients was observed by Pearson linear correlation analysis.Results The levels of serum Visfatin,NF-κB and CD63,PAC-1 and CD62P in angina pectoris group were higher than those in healthy group,the differences were statistically significant(P<0.01).Serum levels of Visfatin,NF-κB and CD63,PAC-1 and CD62P in the low risk group were lower than those in the middle risk group and high-risk group,and these in the middle risk group were lower than the high risk group,the differences were statistically significant(P<0.05).Pearson linear correlation analysis showed that serum visfatin and NF-κB were positively correlated with CD63 and PAC-1(r=0.671,0.591,0.507,0.460,P<0.05).There was no significant correlation between the two and CD62P(P>0.05).Conclusion Visfatin and NF-κB were correlated with platelet activation parameters CD63 and PAC-1 in patients with UA.Visfatin,NF-κB and platelet activation parameters can be used as an important indicator for evaluating the condition of UA patients.
作者
孙欣
武艳强
SUN Xin;WU Yanqiang(The Second Department of Cardiology,the Second Hospital of Handan,Hebei Province,Handan 056001,China;the Forth Department of Cardiololgy,Handan Central Hospital,Hebei Province,Handan 056001,China)
出处
《中国医药导报》
CAS
2019年第2期41-44,62,共5页
China Medical Herald
基金
河北省卫生厅科技计划项目(20181661)
