摘要
目的分析miR-378与非小细胞肺癌(NSCLC)患者临床病理特征和预后的关系。方法共有120名接受肺叶切除术的NSCLC患者入选。收集临床资料和miR-378表达量,采用单变量和多变量COX回归分析,分析miR-378表达与NSCLC临床预后之间的关系。结果 120例NSCLC中,72例高表达miR-378,48例低表达。年龄、性别、肿瘤大小、病理类型和分化程度在低表达组与高表达组间差异无统计学意义(P>0. 05)。miR-378的表达与淋巴结和TNM分期相关(χ~2=6. 899 8,P=0. 001;χ~2=10. 551,P=0. 005)。多变量cox回归结果表明,miR-378高表达是NSCLC患者独立的预后因子(无病生存期和总生存期)(HR=1. 69,95%CI:1. 17-2. 45,P=0. 005; HR=2. 38,95%CI1. 67-3. 91,P <0. 001)。结论miR-378与NSCLC的TNM分期和淋巴结转移密切相关,是NSCLC患者预后的独立危险因素。
Objective To explore the relationship between miR-378 and clinicopathological features and prognosis of non-small cell lung cancer(NSCLC).Methods A total of 120 patients with NSCLC who underwent lobar pneumonectomy were enrolled.Univariate and multivariate COX regression analysis were used to analyze the relationship between the expression of miR-378 and the clinicopathological features of NSCLC.Results The expression of miR-378 in 120 cases of NSCLC was highly expressed in 72 cases and lowly expressed in 48 cases.There was no significantly difference in age,sex,tumor size,pathology type,and differentiation between the low and high expression group(P>0.05).The expression of miR-378 was related to lymph nodes and TNM stage(χ^2=6.295,P=0.043;χ^2=6.268,P=0.045).Multivariate cox regression results indicated that high expression of miR-378 was independently associated with prognosis(both disease-free survival and overall survival)in patients with NSCLC(HR=1.69,95%CI:1.17-2.45,P=0.005;HR=2.38,95%CI:1.67-3.91,P<0.001).Conclusion miR-378 is closely related to TNM staging and lymph node metastasis of NSCLC and is an independent risk factor for the prognosis of NSCLC patients.
作者
王鑫
牟方红
张春艳
WANG Xin;MOU Fang-hong;ZHANG Chun-yan(Kaizhou District People's Hospital,Chongqing 405400,China)
出处
《临床肺科杂志》
2019年第2期226-230,共5页
Journal of Clinical Pulmonary Medicine
