摘要
目的观察加味柴牡四物汤对急性心力衰竭患者心功能指标及血清肌钙蛋白T、脑钠肽(BNP)水平的影响。方法将90例患者随机分为两组。对照组给予常规西医方案治疗,观察组在对照组治疗的基础上,给予加味柴牡四物汤口服治疗。治疗2周后,观察两组治疗前后中医证候积分、Lee氏心衰积分、心功能指标[左心室收缩末容积(LVESV)、左心室舒张末期容积(LVEDV)、左心室射血分数(LVEF)、心脏每搏输出的量(SV)]、血清肌钙蛋白T及BNP水平变化。结果观察组总有效率为91.11%,优于对照组的73.33%(P <0.05)。两组治疗前中医证候积分、Lee氏心衰积分、LVESV、LVEDV、血清肌钙蛋白T、BNP、LVEF、SV水平比较,差异无统计学意义(均P> 0.05)。两组治疗后中医证候积分、Lee氏心衰积分、LVESV、LVEDV、血清肌钙蛋白T、BNP水平均明显降低(均P <0.05),而LVEF、SV水平则均明显升高(均P <0.05),且观察组改善状况均明显优于对照组(均P <0.05)。结论加味柴牡四物汤能够降低血清肌钙蛋白T、BNP水平,提高急性心力衰竭患者心功能,可明显改善患者临床症状。
Objective:To investigate the effects of Modified Chaimu Siwu Decoction on cardiac function index and levels of serum troponin T and BNP in patients with acute heart failure.Methods:90 patients were randomly divided into two groups.The control group were treated with routine Western medicine,while the observation group were treated with Modified Chaimu Siwu Decoction on that basis.After 2 weeks′treatment,TCM syndrome scores,Lee′s heart failure scores,cardiac function index(LVESV,LVEDV,LVEF,SV),and levels of serum troponin T and BNP were observed before and after treatment.Results:The total effective rate of the observation group(91.11%)was significantly better than that of the control group(73.33%)(P<0.05).Before treatment,there was no significant difference in TCM syndrome scores,Lee′s heart failure scores,LVESV,LVEDV and levels of serum troponin T,BNP and SV(P >0.05).After treatment,TCM syndrome scores,Lee′s heart failure scores,LVESV,LVEDV and levels of serum troponin T and BNP were significantly decreased(P<0.05),while the levels of LVEF and SV were significantly increased(P<0.05),and the improvements of the observation group were significant better than those of the control group(P<0.05).Conclusion:Modified Chaimu Siwu Decoction can reduce the levels of serum troponin T and BNP,improve the cardiac function of patients with acute heart failure,and significantly improve the clinical symptoms of patients.
作者
陈婷
叶炯
赵稼萤
Chen Ting;Ye Jiong;Zhao Jiaying(TCM Hospital of Jiading District in Shanghai,Shanghai 201899,China)
出处
《中国中医急症》
2019年第1期91-93,101,共4页
Journal of Emergency in Traditional Chinese Medicine
基金
上海市嘉定区卫生和计划生育委员会项目(2015-QN-ZYY-07)
