摘要
目的探讨单胚胎移植应用于宫颈锥切术后不孕症患者IVF治疗的临床妊娠结局及意义。方法选择2016年1-10月在我院行IVF-ET治疗后有胚胎移植的宫颈锥切术后患者,根据移植胚胎个数将患者分为单胚胎移植组(A组,40例)和双胚胎移植组(B组,40例),比较两组的一般情况和临床妊娠结局。结果 A、B两组患者的年龄、不孕年限、体重指数、Gn天数、Gn总量、HCG日E2水平、获卵数等比较均无显著性差异(P>0.05)。两组临床妊娠率、流产率、活产率、早产率、剖宫产率比较均无显著性差异(P>0.05),A组的多胎妊娠率(3.38%)显著低于B组(33.33%),差异有统计学意义(P<0.05)。B组有4例发生极低/低体重儿出生,有1例发生围产儿死亡,有1例发生巨大胎儿出生。A组未发生1例围生期风险。结论在IVF宫颈锥切术后不孕症患者中行单胚胎移植不仅不降低活产率,而且能有效降低多胎率,进而可能降低患者的妊娠期及围生期风险。
Objective To investigate the IVF pregnancy outcome and significance of single embryo transfer applied to infertile patient after cervical conization.Methods The study was contained 80 infertile patients after cervical conization who accepted IVF-ET treatment in our center from January 2016 to October 2016.They were divided to two groups:the patients were received single embryo transfer in group A(n=40)and the patients were received double embryos transfer in group B(n=40).The clinical status and outcome were compared between the two groups.Results There were no significant differences in age,duration of infertility,BMI,days of gonadotropin used,total gonadotropin used,The number of oocytes retrieved,etc between the two groups(P>0.05).There were no significant differences in Clinical pregnancy rate,abortion rate,live birth rate,preterm birth rate,cesarean section rate(P>0.05).The multiple pregnancy rate in group A(3.38%)was significantly lower than that in group B(33.33%)(P<0.05).In group B,there were 4 cases of very low/low birth weight infants were born,1 case of perinatal death occurred,and 1 case of a large fetus was born.In group A,there was none case of perinatal risk occur.Conclusion In patients with cervical conization,single embryo transplantation does not affect the live birth rate,and beautiful reduce the multiple fetal rate,this may further reduce the risk of pregnancy and perinatal period in patients.
作者
苏琼
伍琼芳
SU Qiong;WU Qiongfang(Center for Reproductive Medicine,Jiangxi Maternal and Child Health Hospital,Nanchang 330006,China)
出处
《江西医药》
CAS
2018年第12期1369-1371,1392,共4页
Jiangxi Medical Journal
基金
江西省卫生厅科技计划课题项目
编号20171123
关键词
单胚胎移植
宫颈锥切术
体外受精-胚胎移植
妊娠结局
Single embryo transfer
Cervical conization
In vitro fertilization-embryo transfer
Pregnancy outcomes
