摘要
Ghrelin是生长激素促分泌素受体的内源性配体,是一种主要从胃中释放的小肽,是具有刺激脑垂体分泌生长激素作用的一种蛋白,同时也具有刺激食欲和新陈代谢的作用。近年来越来越多的实验和研究证实Ghrelin和心血管系统疾病之间存在密不可分的关系,包括增强内皮和血管功能,预防动脉粥样硬化,抑制交感神经兴奋,降低血压,降低致命性心律失常的发生率,减少细胞凋亡和抑制心室重构,改善心力衰竭等。尽管如此,Ghrelin的很多作用机制尚不明确,还有待大量的实验研究证实,现主要对Ghrelin与心血管系统疾病之间的关系进行综述。
Ghrelin is an endogenous ligand of growth hormone secretagogue receptor,and it s a peptide released primarily from stomach.It is a potent stimulator of growth hormone secretion from the pituitary gland and is known for its regulation of appetite and metabolism.There is also a strong relationship between Ghrelin and the cardiovascular system.Ghrelin shows robust cardioprotective effects including enhancing endothelial and vascular function,preventing atherosclerosis,inhibiting sympathetic drive,and decreasing blood pressure.Exogenous administration of ghrelin preserves cardiac function,reduces the incidence of fatal arrhythmias,and attenuates apoptosis and ventricular remodeling,leading to improvements in heart failure.There remains a substantial amount of researches needed to fully understand its clinical significance in cardiovascular disease.This article reviews the relationship between Ghrelin and cardiovascular disease.
作者
马涛
宗刚军
MA Tao;ZONG Gangjun(Department of Cardiology,Wuxi Clinical College,Anhui Medical University,Wuxi 214044,Jiangsu,China;Department of Cardiology,PLA 101 Hospital,Wuxi 214044,Jiangsu,China)
出处
《心血管病学进展》
CAS
2019年第1期139-142,共4页
Advances in Cardiovascular Diseases
基金
国家自然科学基金(81371657)
无锡市卫生计生委科研项目(z201608)
