摘要
目的探讨乳腺原发性鳞状细胞癌的临床病理特征与超声造影诊断的相关性。方法采用回顾性随机样本抽签的研究方法,选择诊治的乳腺肿块80例患者,其中病理确诊为良性肿块60例(良性组),鳞状细胞癌20例(恶性组),两组都进行常规超声与超声造影检查,并进行了免疫组化、病理特征的调查与相关性分析。结果良性组患者中ER阳性率为53.3%,恶性组为60.0%;良性组患者中PR阳性率为50.0%,而恶性组为55.0%,对比无差异(P> 0.05)。相对于良性组,恶性组常规超声多表现为后方回声衰减、边界缘毛刺、内部微钙化、乳腺周边高回声(P <0.05)。恶性组超声造影评分为(3.54±0.14)分,良性组的超声造影评分为(1.56±0.24)分,恶性组高于对照组(P <0.05)。超声造影评分在乳腺原发性鳞状细胞癌的不同分化类型、Dukes分期、淋巴结转移患者中的对比差异明显(P <0.05),而在不同ER与PR免疫组化阳性患者中的对比无差异。Spearman等级相关系数分析显示:恶性组患者的分化类型、Dukes分期、淋巴结转移等病理特征与超声造影评分也存在相关性(γ=0.341,0.368,-0.289,P <0.05)。结论常规超声诊断乳腺原发性鳞状细胞癌能有很好的影像学特征,与超声造影评分情况有相关性,从而为疾病诊断提供很好的参考。
Objective To investigate the correlation between clinical pathologic features and ultrasonographic diagnosis of primary squamous cell carcinoma of the breast. Methods A retrospective random sample sampling method were used,80 patients with breast masses that included 60 benign masses (benign group) and 20 squamous cell carcinoma (malignant group) were selected.Ultrasound and contrast-enhanced ultrasonography were performed,and immunohistochemistry,pathological features were recorded and given correlation analysis. Results The positive rates of ER were 53.3% in the benign group and 60.0% in the malignant group,the positive rate of PR in the benign group were 50.0%,and that in the malignant group were 55.0% that compared were not significantly difference ( P >0.05).Compared with the benign group,the conventional ultrasound in the malignant group were more showed multiple posterior echo attenuation,border edge burr,internal microcalcification,and high echo around the breast ( P <0.05).The malignant contrast score were (3.54±0.14) points in the malignant group and were (1.56±0.24) points in the benign group,and he malignant group were higher than the control group ( P <0.05).Contrast-enhanced ultrasonography scores were significantly different in different types of differentiation,Dukes stage,and lymph node metastasis of primary breast squamous cell carcinoma ( P <0.05),but there were no difference in contrast between different ER and PR immunohistochemical patients.Spearman rank correlation coefficient analysis showed that there were correlations between pathological features such as differentiation type,Dukes stage and lymph node metastasis in patients with malignant group (γ=0.341,0.368,-0.289, P <0.05). Conclusion Conventional ultrasound diagnosis of primary squamous cell carcinoma of the breast can have good imaging features,and it is related to the ultrasound contrast score,which provides good reference for disease diagnosis.
作者
王淼
董鑫
WANG Miao;DONG Xin(Shunyi Hospital of Beijing Chinese Medicine Hospital,Beijing,101300)
出处
《实用癌症杂志》
2019年第1期61-64,共4页
The Practical Journal of Cancer
基金
中西医结合治疗肿瘤协同创新中心资助项目(编号:2013-XRCX-05)
关键词
超声造影
乳腺原发性鳞状细胞癌
病理特征
相关性
Contrast-enhanced ultrasound
Primary squamous cell carcinoma of the breast
Pathological features
