摘要
目的探究对炎症性肠病(Inflammatory bowel disease,IBD)患者实施美沙拉嗪与益生菌联合治疗的效果,为临床提供指导。方法随机将2015年8月至2018年2月本院收治的102例IBD患者分为观察组(51例,应用美沙拉嗪与益生菌联合治疗)和对照组(51例,应用美沙拉嗪治疗)。对比两组患者的总有效率、炎症因子水平及不良反应发生率。结果观察组患者总有效率(98.04%)相比对照组(82.35%)明显更高,差异有统计学意义(P<0.05);观察组患者治疗后C反应蛋白(7.68±1.23)mg/L、IL-10(22.87±5.42)pg/ml相比对照组(9.89±1.65)mg/L、(32.15±8.23)pg/ml明显更低,差异有统计学意义(P<0.05);观察组患者不良反应发生率(11.76%)和对照组(13.73%),比较差异无统计学意义。结论对炎症性肠病患者实施美沙拉嗪与益生菌联合治疗的效果更佳,可有效缓解炎症反应,促进病情好转。
Objective To investigate the effect of combination therapy with mesalazine and probiotics in patients with IBD(Inflammatory bowel disease)and provide guidance for clinical practice.Methods A total of 102 patients with IBD in Japanese hospital from August 2015 to February 2018 were randomly divided into observation group(51 cases,combined with mesalazine and probiotics)and control group(51 cases with mesalazine).treatment).The total effective rate,inflammatory factor levels,and incidence of adverse reactions were compared between the two groups.Results The total effective rate(98.04%)of the observation group was significantly higher than that of the control group(82.35%),and the difference was statistically significant(P<0.05).The C-reactive protein(7.68±1.23)mg/L after treatment in the observation group.IL-10(22.87±5.42)pg/ml was significantly lower than the control group(9.89±1.65)mg/L and(32.15±8.23)pg/ml,the difference was statistically significant(P<0.05);The incidence of adverse reactions in the observation group(11.76%)and the control group was 13.73%,there was not statistically significant.Conclusion The combination of mesalazine and probiotics is more effective in patients with inflammatory bowel disease,which can effectively alleviate the inflammatory response and promote the improvement of the condition.
作者
陈春晓
曾长镜
邓冬梅
Chen Chunxiao;Zeng Changjing;Deng Dongmei(Department of Gastroenterology,Guiping People' s Hospital,Guigang City,Guangxi Zhuang Autonomous Region,Guigang,Guangxi,537200,China)
出处
《当代医学》
2019年第2期79-81,共3页
Contemporary Medicine
关键词
炎症性肠病
美沙拉嗪
益生菌
效果
Inflammatory bowel disease
Mesalazine
Probiotics
Effect
