摘要
目的:研究重症急性左心衰竭患者应用有创呼吸机辅助通气联合吗啡治疗的临床效果。方法:选取本院2015年1月-2017年1月就诊的重症急性左心衰竭患者92例作为研究对象,按照随机数字表法将其分为对照组和研究组,各46例。对照组在临床治疗中单独应用有创呼吸机方案,研究组应用有创呼吸机辅助通气联合吗啡方案,观察比较两组治疗前后的生命体征指标水平、急性生理与慢性健康(APACHEⅡ)评分、血浆脑钠肽(BNP)水平、临床疗效和28 d生存情况。结果:治疗后,研究组pH、动脉氧分压(PaO_2)和动脉血氧饱和度(SaO_2)指标水平均明显高于对照组,心率(HR)、BNP指标水平和APACHEⅡ评分均明显低于对照组,差异均有统计学意义(P<0.05)。研究组临床总有效率为95.65%、28 d生存率为93.48%,均明显高于对照组的76.09%和78.26%,差异均有统计学意义(x^2=7.256、4.390,P=0.001、0.001)。结论:重症急性左心衰竭患者采取有创呼吸机辅助通气联合吗啡方案治疗,能够在短时间内缓解患者临床症状表现,稳定患者生命体征情况,达到预期抢救效果,对于保证患者生命安全、提高生存质量均具有重要作用。
Objective:To investigate the clinical effect of invasive invasive ventilator assisted ventilation combined with Morphine in patients with severe acute left heart failure.Method:A total of 92 patients with severe acute left heart failure treated in our hospital from January 2015 to January 2017 were selected as the research objects.According to the random number table method,they were divided into control group and study group,46 cases in each group.The control group was treated with invasive ventilator alone,the study group was treated with invasive ventilator assisted ventilation combined with Morphine.The levels of vital signs,acute physiology and chronic health(APACHEⅡ)score,plasma brain natriuretic peptide(BNP)before and after treatment,clinical efficacy and 28 d survival between the two groups were observed and compared.Result:After treatment,the levels of pH,PaO2 and SaO2 in the study group were significantly higher than those in the control group,the levels of HR,BNP and APACHEⅡscore were significantly lower than those in the control group,the differences were statistically significant(P<0.05).The clinical total effective rate in the study group was 95.65%and 28 d survival rate was 93.48%,which were significantly higher than 76.09%and 78.26%in the control group,the differences were statistically significant(字2=7.256,4.390,P=0.001,0.001).Conclusion:Invasive ventilator assisted ventilation combined with Morphine regimen in the treatment of patients with severe acute left heart failure can relieve clinical symptoms of patients in a short period of time,stabilize the patient’s vital signs,achieve the desired rescue effect and play an important role in ensuring the safety of patients and improve the quality of life.
作者
吴家圣
曾汇霞
吴海宾
廖梅嫣
尹志斌
WU Jiasheng;ZENG Huixia;WU Haibin(Zhaoqing Second People’s Hospital,Zhaoqing 526040,China)
出处
《中国医学创新》
CAS
2019年第2期5-8,共4页
Medical Innovation of China
基金
广东省科技计划项目(2012B061700048)
关键词
重症急性左心衰竭
有创呼吸机辅助通气
吗啡
生命体征
Severe acute left heart failure
Invasive ventilator assisted ventilation
Morphine
Vital signs
