摘要
目的:探讨微创经皮肾镜钬激光碎石术对复杂性肾结石的疗效观察及血清学指标比较。方法:选取2016年4月-2017年3月本院收治的行手术治疗的复杂性肾结石患者70例作为研究对象,按照随机数字表法将其分为对照组和试验组,各35例。对照组实施开放性肾切开取石术,试验组实施经皮肾镜钬激光碎石术,记录并比较两组手术时间及术中出血量、临床疗效、血清肾功能指标肌酐(Scr)、尿素氮(BUN)、胱抑素C(CysC)以及炎症因子降钙素原(PCT)、超敏C反应蛋白(hs-CRP)水平。结果:试验组的手术时间为(69.32±10.71)min和术中出血量为(56.24±11.49)mL,均明显少于对照组的(92.15±12.33)min和(108.46±13.62)mL,差异均有统计学意义(P<0.05)。试验组的总有效率为94.29%明显高于对照组的77.14%,差异有统计学意义(x^2=4.200,P<0.05)。试验组术后血清肾功能指标CysC、BUN、Scr及炎症因子指标PCT及hs-CRP水平均明显优于对照组,差异均有统计学意义(P<0.05)。结论:经皮肾镜钬激光碎石术治疗复杂性肾结石,不仅对肾功能损伤小,疗效显著,且能平衡机体炎症系统,值得进一步推广。
Objective:To investigate the effect of minimally invasive percutaneous nephrolithotomy holmium laser lithotripsy on complicated renal calculi and comparison of serological indexes.Method:A total of 70 patients with complicated renal calculi treated surgically in our hospital from April 2016 to March 2017 were selected as the study objects.According to the random number table method,they were divided into control group and experimental group,35 cases in each group.The control group was performed open nephrolithotomy,the experimental group was performed percutaneous nephrolithotomy holmium laser lithotripsy.The operation time, intraoperative bleeding volume,clinical efficacy,creatinine(Scr),urea nitrogen(BUN),cystatin C(CysC)levels of serum renal function indicators,procalcitonin(PCT)and hypersensitive C protein(hs-CRP)levels of inflammatory factors between the two groups were recorded and compared.Result:The operation time and intraoperative bleeding volume in the experimental group were(69.32±10.71)min and(56.24±11.49)mL respectively,which were significantly less than(92.15±12.33) min and(108.46±13.62)m L in the control group,the differences were statistically significant(P<0.05).The total effective rate of the experimental group was 94.29%,which was significantly higher than 77.14% of the control group,the difference was statistically significant( χ^2=4.200,P<0.05).The CysC,BUN,Scr levels of serum renal function indicators,PCT and hs-CRP levels of inflammatory factors in the experimental group were significantly better than those in the control group,the differences were statistically significant(P<0.05).Conclusion:Percutaneous nephrolithotomy holmium laser lithotripsy in the treatment of complicated renal calculi is not only little damage to the renal function,efficacy is remarkable,but also can balance the inflammatory system of body.It is worthy of further popularization.
作者
冯燕
FENG Yan(The Fourth Affiliated Hospital of Nanchang University,Nanchang 330002,China)
出处
《中国医学创新》
CAS
2018年第36期89-92,共4页
Medical Innovation of China
关键词
复杂性肾结石
经皮肾镜钬激光碎石术
肾功能
炎症因子
Complicated renal calculi
Percutaneous nephrolithotomy holmium laser lithotripsy
Renal function
Inflammatory factors
