摘要
目的:探讨血塞通预防糖尿病肾病透析患者动静脉内瘘血栓形成的作用。方法:选取2016年1月-2017年10月江西中医药大学附属医院肾病科收治的糖尿病肾病血液透析患者60例作为研究对象,根据术后不同的干预方法将其分为观察组与对照组,各30例。对照组行常规饮食指导,观察组在对照组的基础上加用血塞通片,比较两组治疗后的动静脉内瘘血栓形成、治疗前后的凝血功能变化、动静脉内瘘成熟时间及用药期间不良反应发生情况。结果:观察组治疗1、7个月后的动静脉内瘘血栓形成的发生率分别为0、3.33%均明显低于对照组的13.33%、23.33%,差异均有统计学意义(P<0.05)。治疗后,观察组凝血酶原、凝血酶时间均明显长于对照组,纤维蛋白原水平明显低于对照组,动静脉内瘘成熟时间明显短于对照组,差异均有统计学意义(P<0.05)。两组用药期间尚未出现不良反应,均顺利完成治疗。结论:血塞通预防糖尿病肾病患者动静脉内瘘血栓形成,具有显著应用效果。
Objective:To investigate the role of Xuesaitong in preventing arteriovenous fistula thrombosis in patients with diabetic nephropathy.Method:A total of 60 patients with diabetic nephropathy who were undergone hemodialysis admitted in the Department of Nephrology, Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine from January 2016 to October 2017 were selected as the study objects.According to different intervention methods after operation,they were divided into observation group and control group,30 cases in each group.The control group was received routine dietary guidance,the observation group was given Xuesaitong Tablets on the basis of the control group.Thrombosis of arteriovenous fistula after treatment, changes of coagulation function before and after treatment,maturation time of arteriovenous fistula and adverse reactions during medication between the two groups were compared.Result:The incidence of arteriovenous fistula thrombosis in the observation group were 0% and 3.33% respectively after treatment 1 and 7 months,which were significantly lower than 13.33% and 23.33% in the control group,the differences were statistically significant(P<0.05).After treatment, the time of prothrombin and thrombin in the observation group were significantly longer than those in the control group,fibrinogen level was significantly lower than that in the control group,the maturation time of arteriovenous fistula was significantly shorter than that in the control group,the differences were statistically significant(P<0.05). There were no adverse reactions during the medication period in two groups, and the treatment were successfully completed.Conclusion:Xuesaitong can prevent arteriovenous fistula thrombosis in patients with diabetic nephropathy and has significant application effects.
作者
李庆珍
刘佩佩
赵纪生
LI Qingzhen;LIU Peipei;ZHAO Jisheng(Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine,Nanchang 330006,China)
出处
《中国医学创新》
CAS
2018年第36期22-25,共4页
Medical Innovation of China
基金
江西省卫计委中医药科研课题(2015A132)
关键词
动静脉内瘘
血栓
血塞通
糖尿病肾病
透析
Arteriovenous fistula
Thrombosis
Xuesaitong
Diabetic nephropathy
Dialysis
