摘要
目的研究泮托拉唑联合丹红注射液治疗消化性溃疡的临床效果及对血浆胃泌素、胃动素、脑钠肽(BNP)和心功能的影响。方法 80例消化性溃疡患者按抽签法随机分组,对照组40例,试验组40例。对照组采用泮托拉唑80mg,加入质量浓度为50g·L-1的葡萄糖250mL静脉滴注,每日1次。试验组在对照组基础上,加用丹红注射液40mL,加入质量浓度为50g·L-1的葡萄糖250mL静脉滴注。疗程均为4周。观察2组胃泌素、胃动素、心功能、BNP、不良反应和疗效。结果治疗后,试验组胃泌素、胃动素(80.21±18.69,360.21±20.04ng·mL-1)显著低于对照组(102.30±19.86,390.64±21.02ng·mL-1)(P<0.05);试验组每分钟搏出量(SV),心脏指数(CI),每分钟心输出量(CO)和左心室功能(LVEF)(59.39±11.89mL,2.97±0.50min·m-2,4.89±0.34L·min-1和50.02%±5.30%)显著高于对照组(53.92±10.03mL,2.49±0.45min·m-2,3.02±0.30L·min-1和45.84%±5.07%)(P<0.05);试验组BNP 870.27±102.28μg·L-1显著低于对照组504.30±114.35μg·L-1(P<0.05);试验组不良反应总发生率7.50%(3/40)显著低于对照组25.00%(10/40)(P<0.05);试验组总有效率95.00%(38/40)显著高于对照组72.50%(29/40)(P<0.05)。结论泮托拉唑联合丹红注射液治疗消化性溃疡疗效满意,能减少胃泌素、胃动素以及BNP的表达,可改善患者的心功能。
Objective To study the curative efficacy of pantoprazole combined with Danhong Injections in the treatment of peptic ulcer and its effects on plasma gastrin,motilin,brain natriuretic peptide(BNP)and cardiac function.Methods 80 cases of peptic ulcer patients were grouped by random,the control group(n=40)and the experimental group(n=40).The control group were treated with pantoprazole.The infusion(each times 80 mg mixed with 50 g·L^-1 glucose 250 mL)was intravenously given,1 times per day.The experimental group on the basis of control group,was treated with Danhong Injections(each time 40 mL was mixed with 50 g·L^-1 glucose 250 mL),1 times per day.The course of treatment was 4 weeks.Then the gastrin,motilin,cardiac function,BNP,adverse reactions,treatment effect of the 2 groups were observed and compared.Results Gastrin and motilin in the experimental group 80.21±18.69 and 360.21±20.04 ng·mL^-1 were significantly lower than in the control group(102.30±19.86 and 390.64±21.02 ng·mL^-1(P<0.05);minute volume(SV),cardiac index(CI),cardiac output per minute(CO)and lefe ventricular function(LVEF)in the experimental group(59.39±11.89 mL,2.97±0.50 min·m^-2,4.89±0.34 L·min^-1 and 50.02%±5.30%)were significantly higher than in the control group(53.92±10.03 mL,2.49±0.45 min·m^-2,3.02±0.30 L·min^-1 and 45.84%±5.07%)(P<0.05);BNP in the experimental group 870.27±102.28μg·L^-1 was significantly lower than in the control group 504.30±114.35μg·L^-1(P<0.05);the adverse reactions rate in the experimental group 7.50%(3/40)was significantly lower than in the control group 25.00%(10/40)(P<0.05);the total effective rate in the experimental group 95.00%(38/40)was significantly higher than in the control group 72.50%(29/40)(P<0.05).Conclusion Pantoprazole combined with Danhong Injections in the treatment of peptic ulcer can reduce the levels of gastrin and motilin,reduce the BNP expression,and improve the cardiac function in patients.
作者
王珊珊
乔云兰
WANG Shanshan;QIAO Yunlan(Department of Emergency,Anhui Tumour Hospital,Hefei 230000,China)
出处
《西北药学杂志》
CAS
2019年第1期112-115,共4页
Northwest Pharmaceutical Journal
关键词
泮托拉唑
丹红注射液
消化性溃疡
胃泌素
胃动素
脑钠肽
pantoprazole
Danhong Injections
peptic ulcer
gastrin
motilin
brain natriuretic peptide
