摘要
目的观察自拟中药癌痛消联合美施康定治疗正虚瘀阻型重度癌痛患者的临床效果。方法将符合入组标准的62例患者随机分为AB组和BA组,采用自身交叉对照设计,AB组第1周期单用美施康定治疗(A方案),第2周期予癌痛消联合美施康定治疗(B方案),BA组用药顺序与AB组相反。观察2方案患者疼痛缓解情况、美施康定维持剂量、生活质量改善及伴随症状发生情况。结果 2方案均镇痛效果满意,B方案具有更高的疼痛缓解率,但两方案间比较差异无统计学意义(P>0.05);B方案的NR S评分改善情况好于A方案(P<0.05);采用B方案者较A方案者美施康定维持剂量明显减少(P<0.05)、生活质量改善情况更好(P<0.05)、伴随症状发生率较低(P<0.01)。结论中药癌痛消联合美施康定治疗正虚瘀阻型重度癌痛具有较好的临床效果,可减少美施康定剂量及伴随症状,提高患者的生活质量,具有一定的减毒增效作用。
Objective To observe the clinical effect of Chinese medicine Aitongxiao combined with MS contin on cancer patients with severe pain.Methods Using crossover design,62 patients were randomly divided into AB group and BA group.The AB group was treated with methiconidine alone in the first cycle(regimen A),and in the second cycle with the combination of Aitongxiao and MS contin(regimen B).The drug regimen in BA group is opposite to that in AB group.Observation on the pain relief situation of two groups,and the NRS records,and the maintenance dose of MS contin,and improvement on the quality of life and accompanying symptoms was made.Results The analgesic effect was satisfactory in both groups,and the pain relief rate of regimen B was higher,but there was no statistically significant difference between the two groups(P>0.05).The improvement of NRS score of regimen B was better than that of regimen A(P<0.05).The maintenance dose of MS contin of regimen B was fewer than that of regimen A(P<0.05),the quality of life of regimen B was improved better(P<0.05),and the incidence of complications of regimen B was low(P<0.01).Conclusion Chinese medicine Aitongxiao combined with MS contin has curative effect and is satisfied on severe pain of cancer patients,and can reduce the MS contin dose and the occurrence of symptoms,can improve the patient's quality of life,and has certain advantages.
作者
孟冰琦
MENG Bingqi(Department of Oncology,Heze Hospital of Traditional Chinese Medicine,Shangdong Province,Heze 274000,China)
出处
《中国中医药现代远程教育》
2019年第1期122-124,共3页
Chinese Medicine Modern Distance Education of China
关键词
癌痛消
中西医结合
癌痛
美施康定
正虚瘀阻
combination of traditional Chinese and western medicine
cancer pain
MS contin
asthenia and blood stasis resistance
