摘要
人工韧带移植是临床治疗韧带断裂及缺损性疾病的有效手段,然而现有人工韧带尚存在不能降解及骨愈合不良的问题。该文设计并编织了一种丝素纤维人工韧带材料,并采用多巴胺溶液对材料表面进行涂层改性。对该人工韧带材料的力学性能、体外矿化性能及细胞相容性进行了一系列表征。结果表明,编织法可以快速成型人工韧带材料,通过调节编织角可调控人工韧带材料不同部位的结构。多巴胺涂层可显著提高丝素纤维人工韧带材料的体外矿化性能。矿化层Ca∶P元素比约为1. 57,结构为无定形。细胞试验结果表明,多巴胺涂层人工韧带材料细胞相容性良好。
Artificial ligament transplantation is an effective method for clinical treatment of ligament rupture and defect.However,there are problems of non-degradability and poor bone healing in existing artificial ligaments.In this study,a type of silk fibroin fiber artificial ligament was designed,braided and coated with dopamine solution for surface modification.Then,the mechanical properties,in vitro mineralization and cytocompatibility of the artificial ligament were characterized.Results showed that the artificial ligament could be rapidly produced by braiding and the structure of different parts of the artificial ligament could be easily adjusted by changing the braiding angle.Additionally,dopamine coating could significantly enhance the in vitro mineralization property of the artificial ligament,resulting in the formation of amorphous mineralized layer with the Ca:P ratio of about1.57.Furthermore,the dopamine-coated artificial ligament showed satisfying cytocompatibility.
作者
程志
吴佳蔚
王一婷
王路
关国平
CHENG Zhi;WU Jiawei;WANG Yiting;WANG Lu;GUAN Guoping(Key Laboratory of Textile Science & Technology, Ministry of Education,College of Textiles, Donghua University Shanghai, 201620)
出处
《生物医学工程学进展》
CAS
2018年第4期187-191,226,共6页
Progress in Biomedical Engineering
基金
国家重点研发计划项目(2018YFC1106200)
上海市教育委员会科研创新项目15ZZ032,ZX201503000017)
中央高校基本科研业务费专项(2232015A3-02)
纺织面料技术教育部重点实验室开放课题(KLTST201611)
111project(B07024)
关键词
人工軔带
丝素纤维
多巴胺
表面改性
矿化
artificial ligament
silk fibroin fiber
dopamine
surface modification
mineralization
