摘要
目的探究FOLFOX4与XELOX化疗方案治疗转移性结肠癌的临床效果。方法回顾性分析162例转移性结肠癌患者临床资料,根据化疗方案不同分为F组(n=81)与X组(n=81)。F组患者采用FOLFOX4方案治疗,X组患者则应用XELOX方案进行治疗。比较治疗前及治疗4周期后两组患者细胞学指标、血清肿瘤标志物水平变化,分析治疗4周期后两组患者治疗效果、生活质量及4周期内严重毒副反应发生情况差异。结果治疗4周期后,两组NLR、PLR、RDW、CA19-9、CCSA-2、OPN水平均较治疗前有显著下降,且X组明显低于同期F组,差异均有统计学意义(P均<0.05);两组死亡率比较无统计学意义(P>0.05);X组ORR明显高于F组,差异有统计学意义(P <0.05);X组EORTC-QLQ-CR38功能、症状维度及总分均明显高于F组,差异均有统计学意义(P均<0.05)。严重白细胞减少、口腔黏膜炎、手足综合征及神经毒性发生率均明显低于F组,差异均有统计学意义(P均<0.05)。结论两种化疗方案均能改善转移性结肠癌患者NLR、PLR指标,其中XELOX方案近期疗效更为理想,且毒副作用发生率更低,有利于患者预后恢复。
Objective To explore the clinical effects of FOLFOX4 and XELOX chemotherapy regimens on metastatic colon carcinoma.Methods 162 patients with metastatic colon carcinoma were selected for this study and divided into X group(n=81)and F group(n=81)by the random number table method.F group were treated with the FOLFOX4 regimen,and X group were treated with the XELOX regimen.The levels of cytological indexes[neutrophil/lymphocyte ratio(NLR),platelet/lymphocyte count ratio(PLR),red cell distribution width(RDW)]and serum tumor markers[carbohydrate antigen 19-9(CA19-9),colorectal cancer specific antigen-2(CCSA-2),osteopontin(OPN)]were compared before treatment and after 4 cycles of treatment.And the treatment effects[1.1 version of Response Evaluation Criteria In Solid Tumors(RECIST1.1)]and quality of life[38 items of European Organization for Research and Treatment of Cancer-Quality of Life-colorectal cancer(EORTC-QLQ-CR38)]after 4 cycles of treatment and the occurrence of severe toxic and side effect within 4 cycles[National Cancer Institute-3.0 Version of Conventional Toxicity Criteria(NCI-CTC 3.0)]were analyzed.Results After 4 cycles of treatment,the levels of NLR,PLR,RDW,CA19-9,CCSA-2 and OPN in the two groups were significantly lower than those before treatment,and the levels in X group were significantly lower than those in F group(all P<0.05).There was no significant difference in mortality rate between the two groups(P>0.05).The ORR in X group was significantly higher than that in F group(P<0.05).The scores of function and symptom dimensions and the total score of EORTC-QLQ-CR38 in X group were significantly higher than those in F group(all P<0.05).During 4 cycles of treatment,the incidence rates of severe leukopenia,oral mucositis,hand-foot syndrome and neurotoxicity were significantly higher than those in F group(P<0.05).Conclusion Two chemotherapy regimens can improve the NLR and PLR indexes of patients with metastatic colon carcinoma,the XELOX regimen can have more ideal short-term efficacy,and low incidence
作者
徐琳
XU Lin(Department of Oncology,Suining Central Hospital,Suining 629000,China)
出处
《标记免疫分析与临床》
CAS
2018年第12期1895-1899,共5页
Labeled Immunoassays and Clinical Medicine
