摘要
目的探究早期补充维生素D对早产儿25-(OH)D、IgG、IgM、补体C3、补体C4的影响。方法选取2016年1月至2017年10月在我院收治的140例早产儿为研究对象,采取随机数字表法分为观察组和对照组。对照组采取配方奶粉喂养,观察组出生后3d在对照组的基础上补充维生素D(500U/d),连续7d。测定两组早产儿25-(OH)D、IgG、IgM、补体C3、补体C4,并进行统计学分析。结果两组早产儿3d时各项指标无统计学差异(P>0. 05),第10d,观察组早产儿25-(OH) D升高较对照组明显,差异有统计学意义(P <0.05),两组IgG、IgM水平无明显变化,差异无统计学意义(P>0.05);两组早产儿出生第3d补体C3、补体C4无统计学差异(P>.05),第10d后,观察组补体3、补体C4水平升高幅度均较对照组明显,差异有统计学意义(P<0.05)。结论早期补充维生素D对早产儿有重要的意义,可以提高早产儿的25-(OH)D水平及免疫力,值得临床推广。
Objective To investigate the effect of early use of vitamin D supplementation on 25-(OH)D,IgG,IgM,complement C3 and complement C4 in preterm infants.Methods Forty cases of preterm infants admitted to our hospital from Jan 2016 to October 2017 were selected for the study and randomly divided into observation group and control group.The control group was fed with formula and the observation group was given vitamin D(500U/d)in addition of the control group 3 days after birth for 7 days.The levels of 25-(OH)D,IgG,IgM,complement C3,and complement C4 in preterm infants were measured and statistically analyzed.Results There was no significant difference in each index of preterm infants between the two groups on the third day(P>0.05).On the 10th day,the increase of 25-(OH)D in the preterm infants for the observation group was significantly higher than that of the control group(P<0.05),while there was no significant difference between the two groups for IgG and IgM(P>0.05).There was no significant difference in C3 and C4 between the two groups on the third day(P>0.05).After 10 days,for the observation group,Complement C3,complement C4 levels were significantly higher than the control group,(P<0.05).Conclusion Early use of vitamin D supplementation is of great importance for preterm infants,which can improve the level of 25-(OH)D and immunity in preterm infants.So it is worth of clinical promotion.
作者
赖伟兰
朱细金
陈亚萍
LAI Wei-lan;ZHU Xi-jin;CHEN Ya-ping(Laboratory and Genetic Center,Shaoguan Maternal and Child Health Care Center,Shaoguan 512000,China)
出处
《标记免疫分析与临床》
CAS
2018年第12期1849-1852,共4页
Labeled Immunoassays and Clinical Medicine
