摘要
目的探讨左心房内径(LAD)、超敏C反应蛋白(hsCRP)、脑钠肽(BNP)与老年非瓣膜性心房颤动发生的关系。方法选取2015年2月～2017年12月西安交通大学第一附属医院(以下简称"我院")收治的老年非瓣膜性心房颤动患者103例作为研究组;选取我院同期心电图提示为窦性心律的老年非心房颤动患者90例作为对照组。根据房颤分型将研究组分为阵发性28例,持续性34例,永久性41例;根据研究组患者左心房有无血栓将其分为无血栓组(n=61)和有血栓组(n=42)。比较对照组与研究组、研究组不同房颤分型、无血栓组与有血栓组患者的hsCRP、BNP以及LAD。采用Pearson分析研究组患者hsCRP、BNP与LAD的相关性。采用多因素Logistic回归分析非瓣膜性心房颤动发生的影响因素。结果研究组患者hsCRP、BNP、LAD均高于对照组患者(P <0.05)。永久性、持续性心房颤动患者hsCRP、BNP、LAD高于阵发性心房颤动患者,且永久性心房颤动患者高于持续性心房颤动患者(P <0.05)。左心房有血栓组患者的hsCRP、BNP、LAD均高于无血栓组(P <0.05)。研究组患者LAD与hs CRP、BNP均呈正相关(r=0.468、0.517,均P <0.01)。多因素Logistic回归分析显示,hsCRP、BNP以及LAD均是非瓣膜性心房颤动的影响因素(P <0.01)。结论 hsCRP、BNP以及LAD与老年非瓣膜性心房颤动的发生、发展密切相关。
Objective To investigate the relationship between left atrial diameter(LAD),high sensitivity C reactive protein(hsCRP),brain natriuretic peptide(BNP)and non-valvar atrial fibrillation in elderly patients.Methods A total of103elderly patients with non-valvular atrial fibrillation admitted to the First Affiliated Hospital of Xi′an Jiaotong University("our hospital"for short)from February2015to December2017were enrolled as the study group;90patients with senile non-atrial fibrillation who had sinus rhythm in the same period were selected as the control group.According to the classification of atrial fibrillation,the study group was divided into paroxysmal(n=28),persistent(n=34),permanent(n=41).Patients in the study group were divided into non-thrombotic group(n=61)and thrombotic group(n=42)according to whether there was thrombosis in the left atrium.The hsCRP,BNP and LAD of the patients with different atrial fibrillation,non-thrombosis and thrombosis groups were compared between the control group and the study group and the study group.Pearson analysis was used to analyze the correlation between hsCRP,BNP and LAD in the study group.Multivariate Logistic regression analysis was used to analyze the influencing factors of non-valvar atrial fibrillation.Results The hsCRP,BNP and LAD of the study group were higher than those of the control group(P<0.05).Patients with permanent,persistent atrial fibrillation had higher hsCRP,BNP,and LAD than patients with paroxysmal atrial fibrillation,and patients with permanent atrial fibrillation were more likely to have persistent atrial fibrillation(P<0.05).The levels of hsCRP,BNP and LAD in thrombotic group were higher than those in non-thrombotic group(P<0.05).There was a positive correlation between LAD and hsCRP and BNP in the study group(r=0.468,0.517,all P<0.01).Multivariate Logistic regression analysis showed that hsCRP,BNP and LAD were influencing factors of non-valvar atrial fibrillation in elderly patients(P<0.01).Conclusion HsCRP,BNP and LAD are closely related to the oc
作者
张琳
陈艳炯
吴柏云
刘军辉
洪舟
李娜
封婧
陶丹
ZHANG Lin;CHEN Yanjiong;WU Boyun;LIU Junhui;HONG Zhou;LI Na;FENG Jing;TAO Dan(Department of Laboratory,the First Affiliated Hospital of Xi′an Jiaotong University,Shaanxi Province,Xi′an 710061,China;Department of Emergency,Xi′an NO5Hospital,Shaanxi Province,Xi′an 710082,China;Department of Obstetrics and Gynecology Department,the First Affiliated Hospital of Xi′an Jiaotong University,Shaanxi Province,Xi′an 710061,China)
出处
《中国医药导报》
CAS
2018年第35期66-69,共4页
China Medical Herald
基金
陕西省社会发展科技攻关项目(2016SF-217)
关键词
老年
非瓣膜性心房颤动
左心房内径
超敏C反应蛋白
脑尿钠肽
相关性
Elderly
Non-valvar atrial fibrillation
Left atrial diameter
High sensitivity C reactive protein
Brain natriuretic peptide
Correlation
