摘要
目的观察噻托溴铵联合舒利迭对中重度COPD患者炎症因子、血气指标及肺功能的影响。方法选取2014年9月至2016年10月于本院治疗的中重度COPD患者96例,根据随机数字表法将其分为对照组和观察组,各48例。对照组使用舒利迭治疗,观察组使用噻托溴铵联合舒利迭治疗。对比两组患者的炎症因子水平、血气指标、肺功能以及不良反应发生情况。结果治疗后,两组PCT、IL-6、CRP水平明显降低,且与对照组相比,观察组上述指标均较对照组低,差异具有统计学意义(P <0. 05);治疗后,两组Pa CO2水平均较治疗前显著降低,Pa O2水平较治疗前明显上升,且观察组Pa CO2水平低于对照组,Pa O2水平高于对照组,差异具有统计学意义(P <0. 05);治疗后,两组患者肺功能各项指标均明显提升,且观察组高于对照组,差异具有统计学意义(P <0. 05);对比两组不良反应发生率,差异无统计学意义(P>0. 05)。结论噻托溴铵联合舒利迭治疗中重度COPD患者具有较好的临床效果,可有效改善患者的血气指标,降低患者气道炎症反应,提升患者肺功能,且具有较好的安全性。
Objective To observe the effect of tiotropium bromide combined with seretide on inflammatory factors,blood gas indexes and pulmonary function in patients with moderate-to-severe COPD.Methods 96 patients with moderate-to-severe COPD from September 2014 to October 2016 were selected and randomly divided into the control group(n=48)and the observation group(n=48).The control group was treated with seretide,and the observation group was treated with tiotropium bromide combined with seretide.The inflammatory factors levels,blood gas indexes,pulmonary function,and adverse reactions were compared between the two groups.Results After treatment,the levels of PCT,IL-6 and CRP decreased significantly in the two groups,and the decrease was more pronounced in the observation group than in the control group(P<0.05).The PaCO2 level in the two groups was significantly lower,while the PaO 2 level was significantly higher after treatment than before.And the PaCO2 level in the observation group was lower than that in the control group,while the PaO2 level was higher than that in the control group(P<0.05).The levels of all indexes of pulmonary function in the two groups increased significantly,and they were obviously higher in the observation group than in the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Tiotropium bromide combined with seretide has good clinical effect for patients with moderate-to-severe COPD,and it can effectively improve blood gas indexes,reduce airway inflammatory response and improve pulmonary function,with high safety.
作者
卞庆平
BIAN Qing-ping(Jiangbei Branch of Zhongda Hospital Affiliated to Southeast University, Nanjing, Jiangsu 211500,China)
出处
《临床肺科杂志》
2019年第1期58-60,共3页
Journal of Clinical Pulmonary Medicine
关键词
慢性阻塞性肺疾病
舒利迭
噻托溴铵
炎症因子
血气指标
肺功能
chronic obstructive pulmonary disease
seretide
tiotropium bromide
inflammatory factors
blood gas indexes
pulmonary function
