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硫化氢的生成及其在细胞凋亡和炎性反应中的作用 被引量:8

Generation of H_2S and Its Role in Apoptosis and Inflammatory Response
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摘要 硫化氢(H_2S)是一种无色具有臭味的气体,不仅是畜禽舍内的一种有毒有害物质,而且近年来发现H_2S是继NO、CO之后第3种气体信号分子。H_2S在胃肠中可以通过沙门氏菌、幽门螺旋杆菌等对含硫有机物及硫酸盐分解和还原产生,也可以通过胱硫醚-β-合成酶(CBS)、胱硫醚-γ-裂解酶(CSE)、半胱氨酸转移酶(CAT)与3-巯基丙酮酸硫转移酶(3-MST)等催化L-半胱氨酸等含硫氨基酸产生。H_2S具有多种生理病理学作用,可通过阻断细胞色素C氧化酶而抑制线粒体呼吸(高浓度情况下),造成细胞凋亡,同时也能下调BCL-2及NF-κB等抗凋亡基因表达,促进细胞凋亡;可通过调节Caspase3而抑制细胞凋亡(低浓度情况下),还可以与NF-κB的P65发生巯基化反应促进下游抗凋亡基因表达而发挥抗凋亡作用。高浓度的H_2S可以上调NF-κB、P38、ERKE1/2等基因表达,加重炎症反应;低浓度H_2S可以通过抑制NF-κB信号通路发挥抗炎作用。作者通过综述H_2S气体的生成及其在细胞凋亡和炎性反应中的双重作用,为深入了解H_2S在疾病发展过程中的生理、病理机制提供参考。 H2S is a colorless and odorous gas,it is not only a toxic and harmful substance in livestock houses,but also is the third gas signal molecule after NO and CO.H2S can be produced through decompositing and reducting of sulfur-containing organic compounds and sulfates by Salmonella,Helicobacter pylori,etc.in the gastrointestinal tract,and also through catalyzing sulfurcontaining amino acid such as L-cysteine by cystathionine-β-synthase(CBS),cystathionine-γ-lyase(CSE),cysteine transferase(CAT)and 3-mercapto-pyruvate thiotransferase(3-MST).H2S has a variety of physiological and pathological effects.It can inhibit mitochondrial respiration and blocks apoptosis through blocking cytochrome C(at high content),while also down-regulates anti-apoptotic genes such as BCL-2 and NF-κBto promote apoptosis.It can inhibit apoptosis by regulating Caspase3(at low content),and also can play a thiolation reaction with NF-κB p65 to promote the expression of downstream anti-apoptotic genes and play an anti-apoptotic effect.High concentration of H2S could up-regulate the expression of NF-κB,P38 and ERKE1/2 genes to promote inflammatory responses,low concentrations of H2S could exert anti-inflammatory effects through inhibiting NF-κB signaling pathway.Summarizing the formation of H2S gas and its dual roles inapoptosis and inflammatory response,this paper provides a reference for the understanding of the physiopathological mechanism of H2S in the process of disease development.
作者 张成玉 王月影 许春梅 朱河水 钟凯 李和平 ZHANG Chengyu;WANG Yueying;XU Chunmei;ZHUHeshui;ZHONG Kai;LI Heping(Key Laboratory of Animal Biochemistry and Nutrition ,Ministry of Agriculture, Henan Agricultural University,Zhengzhou 450046 ,China)
机构地区 河南农业大学
出处 《中国畜牧兽医》 CAS 北大核心 2018年第12期3402-3407,共6页 China Animal Husbandry & Veterinary Medicine
基金 国家重点研发计划(2016YFD0500503) 国家自然科学基金(31470120) 河南省基础与前沿技术研究计划(132300410002) 河南省高等学校重点科研项目(17A230016、18A230009).
关键词 硫化氢(H2S) 生成 细胞凋亡 炎性反应 H2S generation cell apoptosis inflammatory reaction
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