摘要
血小板是人体血液中重要的固有成分,在机体各类生理反应中发挥重要作用。近年来,基于血小板及其膜的仿生新型药物传递系统备受关注。与传统药物载体相比,血小板及其膜仿生递药系统具有生物相容性好、血液循环时间长和体内靶向性强等优势。本文介绍了基于血小板及其膜仿生递药系统的特点、种类、载药方式及应用,以期促进血小板及其膜仿生载体在药物递送领域的研究与应用。
Platelet is an important component of human blood,which plays a key role in the physiological and pathological processes.Recently,novel drug delivery system based on platelet and platelet membrane bionics attracted much attention.Compared to the traditional drug carriers,platelet and platelet membrane-based biomimetic drug delivery system has great performances in biocompatibility,longer circulation and stronger ability of targeting.This review presented the features,classifications,drug-loading and applications of platelet and platelet membrane-based biomimetic drug delivery systems,promoting their development and application in the future.
作者
徐剑培
徐群为
王晓琪
辛洪亮
XU Jianpei;XU Qunwei;WANG Xiaoqi;XIN Hongliang(Pharmacy School of Nanjing Medical University,Nanjing 211166,China)
出处
《中国药科大学学报》
CAS
CSCD
北大核心
2018年第6期653-659,共7页
Journal of China Pharmaceutical University
基金
国家自然科学基金资助项目(No.31671018)~~
关键词
血小板
血小板膜
药物载体
生物仿生
纳米
递药系统
blood platelets
platelet membrane
drug carriers
biomimetics
nano
drug delivery system
