摘要
目的探讨血清免疫球蛋白(Ig)A、IgG、IgM检测用于慢性前列腺炎患者疗效评估的可能性。方法检测115例慢性前列腺炎患者、115名体检健康者(正常对照组)的血清IgA、IgG、IgM水平,采用美国国家卫生研究院慢性前列腺炎症状指数(NIH-CPSI)量表(疼痛评分、排尿评分、生活质量评分、总分)在慢性前列腺炎患者治疗前进行评分,并于治疗6周后再次评分,以评价疗效。采用Pearson相关分析评估各项指标之间的相关性,采用多因素Logistic回归分析评估临床疗效与IgA、IgG、IgM的关系。结果慢性前列腺炎组血清IgA、IgG、IgM水平明显高于正常对照组(P=0.000)。高水平IgA、IgG、IgM的慢性前列腺炎患者NIHCPSI量表评分均高于低水平IgA、IgG、IgM患者(P=0.000)。慢性前列腺炎患者血清IgA、IgG、IgM水平与NIH-CPSI量表评分均呈正相关(P<0.05)。不同疗效的慢性前列腺炎患者之间血清IgA、IgG、IgM水平差异均有统计学意义(P=0.000)。多因素Logistic回归分析显示,3个指标对慢性前列腺炎疗效的影响大小依次为Ig G[比值比(OR)=5.003,95%可信区间(CI) 1.822～7.894]、Ig A(OR=3.792,95%CI 3.302～7.580)、Ig M(OR=2.599,95%CI 1.168～5.782)。结论血清Ig A、Ig G、Ig M水平与慢性前列腺炎患者的临床症状及疗效有关。
Objective To investigate the roles of serum immunoglobulin(Ig)A,IgG and IgM determinations in the therapeutic effect evaluation of chronic prostatitis.Methods A total of115patients with chronic prostatitis and115healthy subjects(healthy control group)were enrolled.The National Institutes of Health-chronic prostatitis symptom index(NIH-CPSI)scale(pain score,urinary score,quality of life score and total score)was used before treatment and after treatment for6months,and the therapeutic effect evaluation was performed.The correlation was evaluated by Pearson correlation analysis.The correlations between therapeutic effect with IgA,IgG and IgM were analyzed by multivariant Logistic regression analysis.Results Serum IgA,IgG and IgM levels in chronic prostatitis group were higher than those in healthy control group(P=0.000).In patients with chronic prostatitis with high IgA,IgG and IgM levels,NIH-CPSI scale was higher than those in patients with low IgA,IgG and IgM levels(P=0.000).Serum IgA,IgG and IgM levels of chronic prostatitis patients were positively correlated with NIH-CPSI scale(P<0.05).Serum IgA,IgG and IgM levels of chronic prostatitis patients with different therapeutic effects had statistical significance(P=0.000).Multivariant Logistic regression analysis showed that the influence of serum IgA,IgG and IgM for the treatment of chronic prostatitis from high to low were IgG[odds ratio(OR)=5.003,95%confidence interval(CI)1.822-7.894],IgA(OR=3.792,95%CI3.302-7.580)and IgM(OR=2.599,95%CI1.168-5.782).Conclusions Serum IgA,IgG and IgM have relations with the clinical symptoms and the therapeutic effect of chronic prostatitis.
作者
王家芷
王成
WANG Jiazhi;WANG Cheng(Department of Clinical Laboratory,the Affiliated Hospital of Hangzhou Normal University,Hangzhou 310015,Zhejiang,China;;Department of Pharmacy,the Children's Hospital of Zhejiang University School of Medicine,Hangzhou 310003,Zhejiang,China)
出处
《检验医学》
CAS
2018年第12期1094-1097,共4页
Laboratory Medicine
