摘要
目的比较中晚期宫颈癌同步放化疗患者静脉滴注化疗和动脉灌注(先病变较重侧,后对侧)介入化疗的临床效果。方法选取80例中晚期宫颈癌患者,按照抽签的方式随机分为对照组40例和观察组40例。两组患者均接受常规的调强放疗。同时,对照组患者化疗第1天给予多西他赛75 mg/m^2,避光静脉滴注3 h;第2天给予奈达铂80 mg/m^2,静脉滴注。观察组患者化疗第1天给予多西他赛75 mg/m^2,避光静脉滴注3 h;第2天给予奈达铂80 mg/m^2,动脉灌注介入化疗,先治疗病变较重侧,后对侧。比较两组患者的疗效、肿瘤消退情况及不良反应的发生情况。结果观察组患者的疗效明显优于对照组,差异有统计学意义(P﹤0.01);观察组患者的总缓解率为72.5%,明显高于对照组的42.5%,差异有统计学意义(P﹤0.01)。观察组患者宫颈肿瘤和宫旁肿瘤的消退率分别为95.0%、92.5%,均高于对照组的75.0%、72.5%,差异均有统计学意义(P﹤0.05)。观察组患者的骨髓抑制、胃肠道反应、肝肾功能不全、脱发及末梢神经毒性反应的发生率均低于对照组,差异均有统计学意义(P﹤0.05);观察组患者疼痛伴发热的发生率高于对照组,差异有统计学意义(P﹤0.05)。结论与静脉化疗比较,中晚期宫颈癌同步放化疗患者接受奈达铂动脉介入化疗,可提高近期缓解率,疗效好,不良反应小,用于中晚期宫颈癌患者的治疗安全有效。
Objective To compare the clinical efficacy of intravenous chemotherapy and arterial perfusion(severer side treated first,then the contralateral)in advanced cervical cancer patients with chemoradiotherapy.Method Eighty patients with advanced cervical cancer were enrolled and randomly divided into control group(n=40)and observation group(n=40).All patients underwent conventional intensity-modulated radiotherapy,and the chemotherapy regimen of control group was intravenous drip(avoid light)of Docetaxel75mg/m2for3h on1st day and intravenous drip of Nadeplatin80mg/m2for3h on the 2nd day,while the chemotherapy regimen of observation group was intravenous drip(avoid light)of Docetaxel75mg/m2for3h on1st day and arterial perfusion interventional chemotherapy of Nadeplatin80mg/m2(severer side treated first,then the contralateral)on the 2nd day.The efficacy,tumor regression and incidence of adverse reactions were compared between the two groups.Result The recent curative total effective rate of patients in observation group was significantly higher than that of patients in control group(P<0.01);the overall response rate of patients in observation group was72.5%,which was significantly higher than that of42.5%in control group(P<0.01).The regression rate of cervical tumor and paratural tumors in observation group were95.0%and92.5%respectively,which were both significantly higher than those(75.0%and72.5%)in control group(P<0.05).The incidences of bone marrow suppression,gastrointestinal reactions,hepatic or renal dysfunction,hair loss and peripheral neurotoxic reaction of patients in observation group were all lower than those of patients in control group(P<0.05).The incidence of pain with fever of patients in observation group was significantly higher than that of in control group(P<0.05).Conclusion Compared to intravenous chemotherapy,Nadeplatin arterial interventional chemotherapy for advanced cervical cancer patients with chemoradiotherapy can improve the short-term remission rate with good efficacy and less adverse reacti
作者
王俊杰
陈菁
李春艳
姚娟
WANG Junjie;CHEN Jing;LI Chunyan;YAO Juan(Department of Gynecological Oncology, Qingdao Center Hospital, Qingdao 266042, Shandong, China)
出处
《癌症进展》
2018年第14期1794-1797,共4页
Oncology Progress
关键词
宫颈癌
动脉介入化疗
静脉化疗
放疗
cervical cancer
arterial interventional chemotherapy
intravenous chemotherapy
radiotherapy