摘要
抗黑色素瘤分化相关基因-5 (MDA5)抗体是一种首先发现于临床无肌病性皮肌炎(CADM)的自身抗体,常见于皮肌炎(DM)患者,临床表现比较特异。MDA5和抗MDA5抗体可能参与了炎性肌病的部分发病机制,研究MDA5和抗MDA5抗体在该病中的作用有重要的临床意义,因此近年受到临床医师的广泛关注。本文总结目前MDA5及其抗体在炎性肌病中的临床意义以及在基础研究中的研究背景及相关进展。
Anti-melanoma-differentiation associated gene 5(MDA5)antibody,which is mainly found in dermatomyositis(DM)patients,was firstly detected in clinically amyopathic dermatomyositis(CADM)patients.DM patients with anti-MDA5 antibodies show some specific clinical manifestations.MDA5 and anti-MDA5 antibodies may play a role in the pathogenesis of inflammatory myopathy.The exploration on roles of MDA5 and anti-MDA5 antibodies in the disease is of great clinical significance,so it has attracted considerable attention from clinicians in recent years.This review summarized the clinical significance of MDA5 and anti-MDA5 antibodies in inflammatory myopathies,as well as the background and recent development in the field of basic research.
作者
田苡箫
李菁
王迁
TIAN Yi-xiao;LI Jing;WANG Qian(Department of Rheumatology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Key Laboratory of Rheumatology and Clinical Immunlogy,Ministry of Education,Beijing 100032,China)
出处
《中华临床免疫和变态反应杂志》
2018年第5期537-544,共8页
Chinese Journal of Allergy & Clinical Immunology
基金
国家自然科学基金(81471615)~~
关键词
黑色素瘤分化相关基因5
皮肌炎
无肌病性皮肌炎
Melanoma differentiation-associated gene-5
Dermatomyositis
Amyopathic dermatomyositis
