摘要
目的探讨子宫颈锥切术后临床病理证实宫颈癌患者行根治性子宫手术前辅助化疗一次的合理性及可行性。方法回顾性分析大连市妇幼保健院2012年5月～2017年1月间94例宫颈癌患者,其中50例行宫颈锥切术临床病理证实宫颈癌后行根治性子宫手术前给予辅助化疗一次的患者为中间化疗组,其余44例宫颈锥切术病理证实宫颈癌后再次子宫根治性手术前未行化疗的患者为未中间化疗组,比较两组手术时间、术中出血量、临床病理情况、淋巴结清扫数及术后发热等各项指标。结果中间化疗组与未中间化疗组比较,RHS LVSI、手术时间、二次手术间隔时间、术中出血量、术后发热及住院时间方面存在显著性差异(P<0.05)。两组在临床分期、病理类型、盆腔淋巴结清扫数等差异无统计学意义(P>0.05)。结论宫颈锥切术后在等待行根治性子宫切除术期间化疗一次,能够阻止病灶的宫旁浸润和癌细胞扩散的发生。
Objective To investigate the rationality and feasibility of adjuvant chemotherapy before radical uterine surgery in the patients with cervical cancer confirmed by clinical pathology after cervical conization.Methods A retrospective analysis was carried out for94cases with cervical cancer from May2012to January2017in Dalian Women and Children's Hospital.Among them,50patients with cervical cancer confirmed by clinical pathology after cervical conization who were given adjuvant chemotherapy before radical uterine surgery were selected as intermediate chemotherapy group.The remaining44patients with cervical cancer confirmed by clinical pathology after cervical conization who were not given chemotherapy before radical hysterectomy were selected as non-intermediate chemotherapy group.The two groups were compared in terms of operation time,intraoperative blood loss,clinical pathology,number of dissected lymph nodes,postoperative fever and other indicators.Results There were significant differences in RHS lymph-vascular space infiltration,surgery time,interval between two operations,intraoperative blood loss,postoperative fever,and length of hospital stay between the intermediate chemotherapy group and the non-intermediate chemotherapy group(P<0.05).There were no statistically significant differences in clinical staging,pathological type,and number of dissected pelvic lymph nodes between the two groups(P>0.05).Conclusion Chemotherapy during the waiting period of radical hysterectomy after cervical conization can prevent parametrial infiltration of lesions and cancer cell spread.
作者
李芝伟
姜继勇
LI Zhiwei;JIANG Jiyong(Department of Gynecology and Obstetrics, Dalian Women and Children’s Hospital, Dalian 116021, China)
出处
《中国现代医生》
2018年第32期51-54,共4页
China Modern Doctor
关键词
宫颈锥切
根治性子宫切除术
淋巴脉管间隙浸润
中间化疗
Cervical conization
Radical hysterectomy
Lymph-vascular space infiltration
Intermediate chemotherapy
