摘要
目的:分析高同型半胱氨酸血症引发造影剂肾病的风险。方法:通过计算机检索Pubmed、Embase和Web of Science数据库中高同型半胱氨酸血症和造影剂肾病(contrast-induced nephropathy,CIN)风险关联关系的相关文献。采用Stata 12.0软件进行Meta分析,基数资料采用相对危险度(relative risk,RR)及其95%置信区间(confidence interval,CI)表示。结果:纳入3篇研究,其中前瞻性研究2篇(1 456例),回顾性分析1篇(684例),Meta分析相关研究发现高同型半胱氨酸血症是造影剂肾病的危险因素(RR=1.65,95%CI=1.36,1.99,P<0.001)。结论:高同型半胱氨酸血症增加造影剂肾病的发病风险。
Objective:To assess the impact of hyperhomocysteinemia on contrast-induced nephropathy(CIN)risk.Method:Electrically searched databases including Pubmed,Embase and Web of Science to collect study about the association between hyperhomocysteinemia and CIN risk.The summary relative risks(RR)and95%confidence intervals(CI)were calculated used Meta-analysis.Statistical software Stata12.0was used for Meta analysis.Result:In the Meta-analysis,three studies were included:one retrospective analysis study(684cases)and two population-based cohort studies(1456cases),Meta-analysis of those3studies found that hyperhomocysteinemia was significantly associated with increased risk of CIN(summary RR=1.65,95%CI=1.39,1.99,P<0.001).Conclusion:There is a possible association between hyperhomocysteinemia and increased risk of CIN.
作者
饶小胖
宋雷
王鹏
徐美华
王霄
刘长江
RAO Xiaopang;SONG Lei;WANG Peng(Chengyang People’s Hospital of Qingdao City,Qingdao 266109,China)
出处
《中外医学研究》
2018年第34期11-13,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
