摘要
[目的]探讨愈肺宁方对慢性阻塞性肺疾病(COPD)稳定期患者的远期疗效影响。[方法]选取2016年1月—2017年1月就诊的COPD稳定期患者60例。随机分为西药组30例,结合组30例;西药组予常规西药治疗,结合组在西药组的基础上予愈肺宁方中药口服治疗。观察患者治疗前后炎症相关指标[白介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)、C-反应蛋白(CRP)]和肺功能[1秒用力呼气容积(FEV1)、用力肺活量(FVC)、FEV1/FVC]的变化情况,通过圣乔治呼吸问卷(SGRQ)评价两组患者治疗前、治疗后1、3、6月呼吸气流受限对生活质量的影响程度。[结果]两组患者治疗后IL-8、TNF-α、CRP较治疗前显著降低,与西药组相比较,结合组降低更为明显;所有患者治疗后FEV1、FVC和FEV1/FVC均较治疗前均有改善,与西药组相比,结合组FEV1/FVC改善更为明显;重复测量方差分析显示:两组患者SGRQ评分在治疗前最高,在治疗后1月最低,然后随时间的增加SGRQ评分呈上升趋势。结合组SGRQ评分在各时间点显著低于西药组(P<0.05)。[结论]愈肺宁方治疗稳定期慢性阻塞性肺疾病患者疗效显著,值得临床推广。
[Objective] Exploration on the long-term effect of yufeining on patients with chronic obstructive pulmonary disease at the stable phase. [Methods] Sixty related patients in our department from January 2016 to January 2017 were selected. They were randomly divided into western medicine group of 30 cases and combination group of 30 cases respectively. The former was treated with conventional western medicine and the latter was given oral administration of Yufeining besides the western medicine. Observe changes of patients with inflammatory-related indicators(IL-8, TNF-α and CRP) and pulmonary function(FEV1, FVC, FEV1 # FVC) before and after treatment. Through the st George’s respiratory questionnaire(SGRQ) scores, the impact of airflow obstruction of two groups on the quality of life was evaluated in the first month, third month and sixth month after treatment. [Results] IL-8, TNF-α and CRP of both groups were significantly decreased after treatment. But, they dropped more significantly in combination group than that in western medicine group. FEV1, FVC and FEV1 # FVC of all patients were improved after treatment. Compared with western medicine group, the improvement of FEV1#FVC in combination group was more obvious. Repeated measurement of variance analysis showed that SGRQ score of two groups was highest before treatment and lowest in the first month after treatment. Then it increased with time. The SGRQ score of combination group was significantly lower than that of western medicine group at each time point(P<0.05). [Conclusion] Yufeining has a significant effect on patients with COPD at the stable phase, worthy of clinical promotion
作者
熊浪
杨三春
杨仁旭
XIONG Lang;YANG Sanchun;YANG Renxu(Department of Respiratory Medicine, Dazhou Traditional Chinese and Western Medicine Hospital, Dazhou 635000,China;affiliated hospital of Chengdu University of TCM,Chengdu 610000, China)
出处
《天津中医药大学学报》
CAS
2018年第6期472-475,共4页
Journal of Tianjin University of Traditional Chinese Medicine
